Optical needle endoscope for safe and precise stereotactically guided biopsy sampling in neurosurgery

Proper treatment of deep seated brain tumors requires correct histological diagnosis which unambiguously necessitates biopsy sampling. Stereotactically guided sampling of biopsies is widely used but bears the danger of incorrect sampling locations and damage to intracerebral blood vessels. Here, we...

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Bibliographic Details
Published in:Optics express 2012-11, Vol.20 (24), p.26117-26126
Main Authors: Göbel, Werner, Brucker, David, Kienast, Yvonne, Johansson, Ann, Kniebühler, Gesa, Rühm, Adrian, Eigenbrod, Sabina, Fischer, Stefan, Goetz, Marcus, Kreth, Friedrich-Wilhelm, Ehrhardt, André, Stepp, Herbert, Irion, Klaus-Martin, Herms, Jochen
Format: Article
Language:English
Subjects:
Animals
Biopsy, Needle - instrumentation
Brain - pathology
Brain - surgery
Brain Neoplasms - diagnosis
Brain Neoplasms - surgery
Endoscopes
Endoscopy - methods
Equipment Design
Mice
Neoplasms, Experimental
Neurosurgical Procedures - instrumentation
Stereotaxic Techniques - instrumentation
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Summary:Proper treatment of deep seated brain tumors requires correct histological diagnosis which unambiguously necessitates biopsy sampling. Stereotactically guided sampling of biopsies is widely used but bears the danger of incorrect sampling locations and damage to intracerebral blood vessels. Here, we present a minimally invasive contact endoscopic probe that can be inserted into the tissue inside a standard biopsy needle and allows for fluorescence detection of both tumorous tissue and intracerebral blood vessels. Outer diameter of our contact probe is smaller than 1.5 mm, field-of-view in the range of several hundred microns; the optical design allows for simultaneous detection and visualization of tissue autofluorescence and selective fluorescence signals from deep seated brain tumors and vasculature as shown on in vivo animal models. We demonstrate the tumor detection capability during stereotactic needle insertion in a clinical pilot trial. Using our probe, we expect stereotactic interventions to become safer and more precise and the technology might ultimately be used also for various other kinds of applications.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.20.026117