Perioperative Serum Brain Natriuretic Peptide and Cardiac Troponin in Elective Intracranial Surgery

Background There are some intracranial insults which are associated with cardiac abnormalities. Studies of these abnormalities have never been carried out in elective intracranial neurosurgery for the removal of brain tumors. Our prospective study aims at quantifying serum cardiac troponin T (cTnT)...

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Bibliographic Details
Published in:Neurocritical care 2012-12, Vol.17 (3), p.395-400
Main Authors: Ruggieri, Francesco, Gemma, Marco, Calvi, Maria Rosa, Nicelli, Elisa, Agarossi, Andrea, Beretta, Luigi
Format: Article
Language:English
Subjects:
Adult
Anesthesia, Inhalation - statistics & numerical data
Anesthesia, Intravenous - statistics & numerical data
Biomarkers
Biomarkers - blood
Body mass index
Brain cancer
Brain damage
Brain Neoplasms - epidemiology
Brain Neoplasms - surgery
Brain research
Cardiac arrhythmia
Critical Care Medicine
Elective Surgical Procedures - adverse effects
Elective Surgical Procedures - statistics & numerical data
Electrocardiography
Female
General anesthesia
Glioma - epidemiology
Glioma - surgery
Hemodynamics
Humans
Hydrocephalus
Hypotension
Informed consent
Intensive
Internal Medicine
Ischemia
Kurtosis
Linear Models
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Natriuretic Peptide, Brain - blood
Neurology
Neurosurgery
Neurosurgical Procedures - adverse effects
Neurosurgical Procedures - statistics & numerical data
Original Article
Patients
Peptide Fragments - blood
Peptides
Perioperative Period
Postoperative Complications - blood
Postoperative Complications - epidemiology
Predictive Value of Tests
Prospective Studies
Risk Factors
Skewness
Surgery
Troponin T - blood
Variables
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Summary:Background There are some intracranial insults which are associated with cardiac abnormalities. Studies of these abnormalities have never been carried out in elective intracranial neurosurgery for the removal of brain tumors. Our prospective study aims at quantifying serum cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) before and after elective intracranial neurosurgery for tumor resection in patients with no history of cardiac abnormality. Methods Pre- and postoperative serum cTnT and NT-proBNP were measured in 108 patients submitted to elective major intracranial surgery for the removal of neoplastic lesions. We tested potentially predictive models for these biomarker serum levels. Results cTnT was undetectable both before and after surgery. Median (IQR) basal NT-proBNP was 35 (18–69) pg/mL and 110 (51–191) pg/mL after surgery. In a multiple linear regression model, basal NT-proBNP was predicted by age, gender, BMI, and the presence of “mass effect” (midline shift or effaced perimesencephalic cisterns on preoperative CT scan) (whole model P  
ISSN:1541-6933
1556-0961
DOI:10.1007/s12028-012-9684-2