Arthropod venoms: A vast arsenal of insecticidal neuropeptides

Arthropods are the most diverse animal group on the planet, and occupy almost all ecological niches. Venomous arthropods are a rich source of bioactive compounds evolved for prey capture and defense against predators and/or microorganisms. These highly potent chemical arsenals represent an available...

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Bibliographic Details
Published in:Biopolymers 2012, Vol.98 (4), p.385-405
Main Authors: Schwartz, Elisabeth F., Mourão, Caroline B. F., Moreira, Karla G., Camargos, Thalita S., Mortari, Márcia R.
Format: Article
Language:English
Subjects:
Animals
arthropod venom
Arthropod Venoms - chemistry
Arthropod Venoms - pharmacology
hymenopteran
insecticidal peptides
Insecticides - chemistry
Insecticides - pharmacology
Nervous System - drug effects
Neuropeptides - chemistry
Neuropeptides - pharmacology
scorpion
spider
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Summary:Arthropods are the most diverse animal group on the planet, and occupy almost all ecological niches. Venomous arthropods are a rich source of bioactive compounds evolved for prey capture and defense against predators and/or microorganisms. These highly potent chemical arsenals represent an available source for new insecticidal compounds as they act selectively on their molecular targets. These toxins affect the invertebrate nervous system and, until the moment, several insecticidal compounds belonging to the class of peptides or polyamine‐like compounds have been purified and characterized from the venom of arachnids and hymenopterans. This review focuses on invertebrate‐specific peptide neurotoxins that have been isolated from the venom of spiders, scorpions, centipedes, ants, and wasps, discussing their potential in pest control and as invaluable tools in neuropharmacology. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 385‐405, 2012.
ISSN:0006-3525
1097-0282
DOI:10.1002/bip.22100