Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer

Objectives Our objective was to examine blood and tissue levels of nitric oxide (NO) and malondialdehyde (MDA), and their correlations with well-known prognostic indicators [total prostate-specific antigen (tPSA),  %free/total PSA (%f/t PSA), pathological stage (pT), and Gleason sum] in patients who...

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Bibliographic Details
Published in:International urology and nephrology 2012-12, Vol.44 (6), p.1691-1696
Main Authors: Dillioglugil, Meltem Ozlen, Mekık, Haluk, Muezzinoglu, Bahar, Ozkan, T. Alp, Demir, Cennet Gural, Dillioglugil, Ozdal
Format: Article
Language:English
Subjects:
Aged
Humans
Male
Malondialdehyde - analysis
Malondialdehyde - blood
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nitric Oxide - analysis
Nitric Oxide - blood
Prognosis
Prostatic Neoplasms - blood
Prostatic Neoplasms - chemistry
Prostatic Neoplasms - diagnosis
Urology
Urology - Original Paper
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Summary:Objectives Our objective was to examine blood and tissue levels of nitric oxide (NO) and malondialdehyde (MDA), and their correlations with well-known prognostic indicators [total prostate-specific antigen (tPSA),  %free/total PSA (%f/t PSA), pathological stage (pT), and Gleason sum] in patients who had radical retropubic prostatectomy (RRP) for localized prostate cancer (PCa) without metastasis. Patients and methods Preoperatively 31 patients’ bloods were obtained for determination of NO, MDA, fPSA, tPSA, and  %f/tPSA ratios. Tissues were obtained from RRP specimens for determination of NO and MDA. Gleason sum was assigned for each patient, and pT was determined according to 2002 TNM staging system. pTs were as follows: 10 pT2a, 7 pT2b, 8 pT2c, 4 pT3a, and 2 pT3b. Gleason sum of the PCa in the RRP specimens was as follows: 5 in 1, 6 in 14, 7 in 14, and 9 in 2 patients. Results There were strong correlations between blood and tissue levels of NO ( r  = 0.83, p  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-012-0221-1