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Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer
Objectives Our objective was to examine blood and tissue levels of nitric oxide (NO) and malondialdehyde (MDA), and their correlations with well-known prognostic indicators [total prostate-specific antigen (tPSA), %free/total PSA (%f/t PSA), pathological stage (pT), and Gleason sum] in patients who...
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| Published in: | International urology and nephrology 2012-12, Vol.44 (6), p.1691-1696 |
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| container_title | International urology and nephrology |
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| creator | Dillioglugil, Meltem Ozlen Mekık, Haluk Muezzinoglu, Bahar Ozkan, T. Alp Demir, Cennet Gural Dillioglugil, Ozdal |
| description | Objectives
Our objective was to examine blood and tissue levels of nitric oxide (NO) and malondialdehyde (MDA), and their correlations with well-known prognostic indicators [total prostate-specific antigen (tPSA), %free/total PSA (%f/t PSA), pathological stage (pT), and Gleason sum] in patients who had radical retropubic prostatectomy (RRP) for localized prostate cancer (PCa) without metastasis.
Patients and methods
Preoperatively 31 patients’ bloods were obtained for determination of NO, MDA, fPSA, tPSA, and %f/tPSA ratios. Tissues were obtained from RRP specimens for determination of NO and MDA. Gleason sum was assigned for each patient, and pT was determined according to 2002 TNM staging system. pTs were as follows: 10 pT2a, 7 pT2b, 8 pT2c, 4 pT3a, and 2 pT3b. Gleason sum of the PCa in the RRP specimens was as follows: 5 in 1, 6 in 14, 7 in 14, and 9 in 2 patients.
Results
There were strong correlations between blood and tissue levels of NO (
r
= 0.83,
p
|
| doi_str_mv | 10.1007/s11255-012-0221-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1221132124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1221132124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-f92b6bdea4c9201c49115ac34838edcd7d1476b30ffeacf1950eaa0fa020f7333</originalsourceid><addsrcrecordid>eNp1kU1LxDAQhoMouq7-AC9S8OKlOpP0Y3tU8QsEL3oO2WSyRrqNJi24_npTV0UET4F3nnlnMi9jBwgnCFCfRkReljkgz4FzzHGDTbCsRc7LWbHJJiAgiRUXO2w3xmcAaGYA22yH8xqhqXHCns5b702mOpP1LsaBss71wenMvzlDn_pStb4zTrWGnlajFih7CX7R-dgn0KWaVr0PMfM2a71WrXsnMyKxVz1lWnWawh7bsqqNtP_1Ttnj1eXDxU1-d399e3F2l2tR8z63DZ9Xc0Oq0A0H1EWDWCotipmYkdGmNljU1VyAtaS0xaYEUgqsAg62FkJM2fHaN81_HSj2cumiprZVHfkhSkyHQsGRFwk9-oM--yF0abtEVVWRjtRgonBN6fShGMjKl-CWKqwkghxjkOsYZIpBjjHIsefwy3mYL8n8dHzfPQF8DcRU6hYUfo3-1_UDhGWTWg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1266427191</pqid></control><display><type>article</type><title>Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer</title><source>Springer Link</source><creator>Dillioglugil, Meltem Ozlen ; Mekık, Haluk ; Muezzinoglu, Bahar ; Ozkan, T. Alp ; Demir, Cennet Gural ; Dillioglugil, Ozdal</creator><creatorcontrib>Dillioglugil, Meltem Ozlen ; Mekık, Haluk ; Muezzinoglu, Bahar ; Ozkan, T. Alp ; Demir, Cennet Gural ; Dillioglugil, Ozdal</creatorcontrib><description>Objectives
Our objective was to examine blood and tissue levels of nitric oxide (NO) and malondialdehyde (MDA), and their correlations with well-known prognostic indicators [total prostate-specific antigen (tPSA), %free/total PSA (%f/t PSA), pathological stage (pT), and Gleason sum] in patients who had radical retropubic prostatectomy (RRP) for localized prostate cancer (PCa) without metastasis.
Patients and methods
Preoperatively 31 patients’ bloods were obtained for determination of NO, MDA, fPSA, tPSA, and %f/tPSA ratios. Tissues were obtained from RRP specimens for determination of NO and MDA. Gleason sum was assigned for each patient, and pT was determined according to 2002 TNM staging system. pTs were as follows: 10 pT2a, 7 pT2b, 8 pT2c, 4 pT3a, and 2 pT3b. Gleason sum of the PCa in the RRP specimens was as follows: 5 in 1, 6 in 14, 7 in 14, and 9 in 2 patients.
Results
There were strong correlations between blood and tissue levels of NO (
r
= 0.83,
p
< 0.001) and MDA (
r
= 0.63,
p
< 0.001), between serum NO and plasma MDA (
r
= 0.88,
p
< 0.001), and finally between tissue NO and tissue MDA (
r
= 0.83,
p
< 0.001). There was also a significant (
p
< 0.05) relationship between all well-known prognostic indicators of PCa (tPSA, %f/tPSA, Gleason sum, and pT) and blood and tissue NO and MDA levels, with single exception of correlation between tissue MDA and Gleason sum (
p
= 0.073).
Conclusion
Clinically appropriate correlations shown in this study indicates that NO and MDA may be used for prognostic assessment of localized PCa, especially if supported with other well-designed studies including higher number of patients through multi-institutional collaboration.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-012-0221-1</identifier><identifier>PMID: 22710971</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Humans ; Male ; Malondialdehyde - analysis ; Malondialdehyde - blood ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Nitric Oxide - analysis ; Nitric Oxide - blood ; Prognosis ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - chemistry ; Prostatic Neoplasms - diagnosis ; Urology ; Urology - Original Paper</subject><ispartof>International urology and nephrology, 2012-12, Vol.44 (6), p.1691-1696</ispartof><rights>Springer Science+Business Media, B.V. 2012</rights><rights>Springer Science+Business Media Dordrecht 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f92b6bdea4c9201c49115ac34838edcd7d1476b30ffeacf1950eaa0fa020f7333</citedby><cites>FETCH-LOGICAL-c372t-f92b6bdea4c9201c49115ac34838edcd7d1476b30ffeacf1950eaa0fa020f7333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22710971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dillioglugil, Meltem Ozlen</creatorcontrib><creatorcontrib>Mekık, Haluk</creatorcontrib><creatorcontrib>Muezzinoglu, Bahar</creatorcontrib><creatorcontrib>Ozkan, T. Alp</creatorcontrib><creatorcontrib>Demir, Cennet Gural</creatorcontrib><creatorcontrib>Dillioglugil, Ozdal</creatorcontrib><title>Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Objectives
Our objective was to examine blood and tissue levels of nitric oxide (NO) and malondialdehyde (MDA), and their correlations with well-known prognostic indicators [total prostate-specific antigen (tPSA), %free/total PSA (%f/t PSA), pathological stage (pT), and Gleason sum] in patients who had radical retropubic prostatectomy (RRP) for localized prostate cancer (PCa) without metastasis.
Patients and methods
Preoperatively 31 patients’ bloods were obtained for determination of NO, MDA, fPSA, tPSA, and %f/tPSA ratios. Tissues were obtained from RRP specimens for determination of NO and MDA. Gleason sum was assigned for each patient, and pT was determined according to 2002 TNM staging system. pTs were as follows: 10 pT2a, 7 pT2b, 8 pT2c, 4 pT3a, and 2 pT3b. Gleason sum of the PCa in the RRP specimens was as follows: 5 in 1, 6 in 14, 7 in 14, and 9 in 2 patients.
Results
There were strong correlations between blood and tissue levels of NO (
r
= 0.83,
p
< 0.001) and MDA (
r
= 0.63,
p
< 0.001), between serum NO and plasma MDA (
r
= 0.88,
p
< 0.001), and finally between tissue NO and tissue MDA (
r
= 0.83,
p
< 0.001). There was also a significant (
p
< 0.05) relationship between all well-known prognostic indicators of PCa (tPSA, %f/tPSA, Gleason sum, and pT) and blood and tissue NO and MDA levels, with single exception of correlation between tissue MDA and Gleason sum (
p
= 0.073).
Conclusion
Clinically appropriate correlations shown in this study indicates that NO and MDA may be used for prognostic assessment of localized PCa, especially if supported with other well-designed studies including higher number of patients through multi-institutional collaboration.</description><subject>Aged</subject><subject>Humans</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Malondialdehyde - blood</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - blood</subject><subject>Prognosis</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - chemistry</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Urology</subject><subject>Urology - Original Paper</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kU1LxDAQhoMouq7-AC9S8OKlOpP0Y3tU8QsEL3oO2WSyRrqNJi24_npTV0UET4F3nnlnMi9jBwgnCFCfRkReljkgz4FzzHGDTbCsRc7LWbHJJiAgiRUXO2w3xmcAaGYA22yH8xqhqXHCns5b702mOpP1LsaBss71wenMvzlDn_pStb4zTrWGnlajFih7CX7R-dgn0KWaVr0PMfM2a71WrXsnMyKxVz1lWnWawh7bsqqNtP_1Ttnj1eXDxU1-d399e3F2l2tR8z63DZ9Xc0Oq0A0H1EWDWCotipmYkdGmNljU1VyAtaS0xaYEUgqsAg62FkJM2fHaN81_HSj2cumiprZVHfkhSkyHQsGRFwk9-oM--yF0abtEVVWRjtRgonBN6fShGMjKl-CWKqwkghxjkOsYZIpBjjHIsefwy3mYL8n8dHzfPQF8DcRU6hYUfo3-1_UDhGWTWg</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Dillioglugil, Meltem Ozlen</creator><creator>Mekık, Haluk</creator><creator>Muezzinoglu, Bahar</creator><creator>Ozkan, T. Alp</creator><creator>Demir, Cennet Gural</creator><creator>Dillioglugil, Ozdal</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer</title><author>Dillioglugil, Meltem Ozlen ; Mekık, Haluk ; Muezzinoglu, Bahar ; Ozkan, T. Alp ; Demir, Cennet Gural ; Dillioglugil, Ozdal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-f92b6bdea4c9201c49115ac34838edcd7d1476b30ffeacf1950eaa0fa020f7333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Humans</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>Malondialdehyde - blood</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - blood</topic><topic>Prognosis</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - chemistry</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Urology</topic><topic>Urology - Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dillioglugil, Meltem Ozlen</creatorcontrib><creatorcontrib>Mekık, Haluk</creatorcontrib><creatorcontrib>Muezzinoglu, Bahar</creatorcontrib><creatorcontrib>Ozkan, T. Alp</creatorcontrib><creatorcontrib>Demir, Cennet Gural</creatorcontrib><creatorcontrib>Dillioglugil, Ozdal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dillioglugil, Meltem Ozlen</au><au>Mekık, Haluk</au><au>Muezzinoglu, Bahar</au><au>Ozkan, T. Alp</au><au>Demir, Cennet Gural</au><au>Dillioglugil, Ozdal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>44</volume><issue>6</issue><spage>1691</spage><epage>1696</epage><pages>1691-1696</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Objectives
Our objective was to examine blood and tissue levels of nitric oxide (NO) and malondialdehyde (MDA), and their correlations with well-known prognostic indicators [total prostate-specific antigen (tPSA), %free/total PSA (%f/t PSA), pathological stage (pT), and Gleason sum] in patients who had radical retropubic prostatectomy (RRP) for localized prostate cancer (PCa) without metastasis.
Patients and methods
Preoperatively 31 patients’ bloods were obtained for determination of NO, MDA, fPSA, tPSA, and %f/tPSA ratios. Tissues were obtained from RRP specimens for determination of NO and MDA. Gleason sum was assigned for each patient, and pT was determined according to 2002 TNM staging system. pTs were as follows: 10 pT2a, 7 pT2b, 8 pT2c, 4 pT3a, and 2 pT3b. Gleason sum of the PCa in the RRP specimens was as follows: 5 in 1, 6 in 14, 7 in 14, and 9 in 2 patients.
Results
There were strong correlations between blood and tissue levels of NO (
r
= 0.83,
p
< 0.001) and MDA (
r
= 0.63,
p
< 0.001), between serum NO and plasma MDA (
r
= 0.88,
p
< 0.001), and finally between tissue NO and tissue MDA (
r
= 0.83,
p
< 0.001). There was also a significant (
p
< 0.05) relationship between all well-known prognostic indicators of PCa (tPSA, %f/tPSA, Gleason sum, and pT) and blood and tissue NO and MDA levels, with single exception of correlation between tissue MDA and Gleason sum (
p
= 0.073).
Conclusion
Clinically appropriate correlations shown in this study indicates that NO and MDA may be used for prognostic assessment of localized PCa, especially if supported with other well-designed studies including higher number of patients through multi-institutional collaboration.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>22710971</pmid><doi>10.1007/s11255-012-0221-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | International urology and nephrology, 2012-12, Vol.44 (6), p.1691-1696 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_1221132124 |
| source | Springer Link |
| subjects | Aged Humans Male Malondialdehyde - analysis Malondialdehyde - blood Medicine Medicine & Public Health Middle Aged Nephrology Nitric Oxide - analysis Nitric Oxide - blood Prognosis Prostatic Neoplasms - blood Prostatic Neoplasms - chemistry Prostatic Neoplasms - diagnosis Urology Urology - Original Paper |
| title | Blood and tissue nitric oxide and malondialdehyde are prognostic indicators of localized prostate cancer |
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