Inflammation in Atrial Fibrillation

Atrial fibrillation (AF) is associated with increased risk for stroke and systemic embolism. There is plausible evidence linking inflammation to the initiation and perpetuation of AF and AF-related thrombosis. Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2,...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2012-12, Vol.60 (22), p.2263-2270
Main Authors: Guo, Yutao, MDR, Lip, Gregory Y.H., MD, Apostolakis, Stavros, MD, PhD
Format: Article
Language:English
Subjects:
Animals
atrial fibrillation
Atrial Fibrillation - blood
Atrial Fibrillation - epidemiology
Atrial Fibrillation - pathology
Biological and medical sciences
Biomarkers - blood
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Case-Control Studies
Chemokines
Cytokines
Drug therapy
Heart
Humans
inflammation
Inflammation - blood
Inflammation - epidemiology
Inflammation - pathology
Inflammation Mediators - physiology
Internal Medicine
Medical sciences
Pathogenesis
Plasma
Proteins
prothrombotic state
Risk Factors
Studies
Thrombosis
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Summary:Atrial fibrillation (AF) is associated with increased risk for stroke and systemic embolism. There is plausible evidence linking inflammation to the initiation and perpetuation of AF and AF-related thrombosis. Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-8) have been associated with AF. Proposed mechanisms linking inflammation and the prothrombotic AF state include endothelial activation/damage, production of tissue factor from monocytes, increased platelet activation, and increased expression of fibrinogen. The present review aims to provide an update on the association of inflammation and AF, including the impact of inflammatory markers on clinical presentation and outcome of AF patients.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2012.04.063