Berbamine inhibits IL-2 receptor expression, but spares IL-2 production and its mRNA expression

The purpose of this paper was to elucidate the mechanism of action of berbamine on the T-lymphocyte mediated immune responses. Effects of berbamine on IL-2 production, IL-2 receptor expression and the interaction between IL-2 and IL-2 receptor were observed. The results clearly demonstrated that ber...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 1998-08, Vol.5 (4), p.269-273
Main Authors: Luo, C.N., Bien, Q.Y., Lin, X., Wan, L.W., Xiao, P.G.
Format: Article
Language:English
Subjects:
berbamine
expression
IL-2
IL-2 receptor
immune response
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Summary:The purpose of this paper was to elucidate the mechanism of action of berbamine on the T-lymphocyte mediated immune responses. Effects of berbamine on IL-2 production, IL-2 receptor expression and the interaction between IL-2 and IL-2 receptor were observed. The results clearly demonstrated that berbamine suppressed the expression of IL-2 receptors on PHA induced T-blast cells, but did not alter the production of IL-2 of mouse splenic cells and human tonsil lymphocytes. Futhermore, the results also showed that berbamine at higher concentrations had a slight inhibitory effect on the interaction between IL-2 and IL-2 receptors, and addition of exogenous IL-2 did not reverse the inhibitory action of berbamine on T-cell proliferation.
ISSN:0944-7113
1618-095X
DOI:10.1016/S0944-7113(98)80065-2