Some lupane-type triterpenes inhibit tumor promotion by 12- O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin

We have found that several lupane-type triterpenes, including lupeol, its acetate, betulin and betulinic acid, inhibit 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation, and that betulinic acid inhibits tumor promotion in two-stage carcinogenesis in mice. Among seven lupane-type trite...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 1995-04, Vol.1 (4), p.309-313
Main Authors: Yasukawa, K., Yu, SY, Yamanouchi, S., Takido, M., Akihisa, T., Tamura, T.
Format: Article
Language:English
Subjects:
12- O-Tetradecanoylphorbol-13-acetate
Antitumor promoter
Betulin
Lupane-type triterpene
Lupeol
Lupeol 3-acetate
Two-stage carcinogenesis
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Summary:We have found that several lupane-type triterpenes, including lupeol, its acetate, betulin and betulinic acid, inhibit 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation, and that betulinic acid inhibits tumor promotion in two-stage carcinogenesis in mice. Among seven lupane-type triterpenes assayed, these compounds inhibited the inflammatory activity induced by TPA in mice. The 50 % inhibitory dose of these compounds for TPA-induced inflammation was 0.4–4.0 μmol. Furthermore, topical application of lupeol, lupeol 3-acetate and betulin markedly suppressed the tumor-promoting effect of TPA (1 μg/mouse) in mouse skin initiated with 7,12-dimethyl-benz[ a]anthracene (50 μg/mouse), at a grade corresponding to that of betulinic acid.
ISSN:0944-7113
1618-095X
DOI:10.1016/S0944-7113(11)80008-5