Synthesis and antitumor activity of new 2-thioand 2-amino-substituted pyrimidines

New 2-S-4,5,6-substituted pyrimidines have been prepared via the reaction of 2-mercaptopyrimidines with allyl-, methallyl-, and substituted-benzyl chlorides, chloroacetamide, and chloracetic, á-bromopropionic, and á-bromocaproic acids. Reactions of 2-methylthio-derivatives with morpholine, piperidin...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2011-06, Vol.45 (3), p.137-140, Article 137
Main Authors: Grigoryan, L. A., Kaldrikyan, M. A., Melik-Ogandzhanyan, R. G., Arsenyan, F. G.
Format: Article
Language:English
Subjects:
Acids
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:New 2-S-4,5,6-substituted pyrimidines have been prepared via the reaction of 2-mercaptopyrimidines with allyl-, methallyl-, and substituted-benzyl chlorides, chloroacetamide, and chloracetic, á-bromopropionic, and á-bromocaproic acids. Reactions of 2-methylthio-derivatives with morpholine, piperidine, and o - and p -anisidines yielded the corresponding 2-amino-derivatives. The antitumor properties of the synthesized compounds have been studied.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0576-0