Cardioactive iridoid glycosides from Eremophila species

Four iridoid glycosides isolated from different species of Eremophila (Myoporaceae) were tested for their effects on the Langendorff rat heart. Melampyroside (1), verminoside (2), ferruloylajugol (3) and catalpol (4) all significantly decreased contractile force in the isolated rat heart test. Withi...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 1997-12, Vol.4 (4), p.325-330
Main Authors: Pennacchio, M., Syah, Y.M., Ghisalberti, E.L., Alexander, E.
Format: Article
Language:English
Subjects:
cardioactive effects
catalpol
Eremophila species
ferruloylajugol
iridoid glycosides
Langendorff heart
melampyroside
Myoporaceae
verminoside
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Summary:Four iridoid glycosides isolated from different species of Eremophila (Myoporaceae) were tested for their effects on the Langendorff rat heart. Melampyroside (1), verminoside (2), ferruloylajugol (3) and catalpol (4) all significantly decreased contractile force in the isolated rat heart test. Within a minute after administration all, except catalpol, significantly increased heart rate and coronary perfusion rate. These results are compared to those of other cardioactive iridoid glycosides described in the literature.
ISSN:0944-7113
1618-095X
DOI:10.1016/S0944-7113(97)80041-4