Antioxidant and antiradical properties of new amino-acid derivatives of aminoalcohols

The antioxidant, antiradical, and membranotropic properties of newly synthesized compounds of the group of N-[3-hydroxy-3-(p-substituted phenyl)-1-propyl] amino acids were studied on model systems in vitro.According to the results, amino-acid derivatives of aminopropanols did not exhibit any signifi...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2010-12, Vol.44 (8), p.421-423
Main Authors: Malakyan, M. G, Vardevanyan, L. A, Yeghiazaryan, D. E, Badzhinyan, S. A, Agababyan, A. G, Gevorgyan, G. A
Format: Article
Language:English
Subjects:
Amino acids
aminopropanols
antioxidant properties
Antioxidants
antiradical activity
Erythrocytes
Glycine
hemolysis
Leucine
Medicine
membranotropic properties
Methionine
Organic Chemistry
Oxidative stress
Peroxidation
Pharmacology/Toxicology
Pharmacy
Radicals
Spectrophotometry
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Summary:The antioxidant, antiradical, and membranotropic properties of newly synthesized compounds of the group of N-[3-hydroxy-3-(p-substituted phenyl)-1-propyl] amino acids were studied on model systems in vitro.According to the results, amino-acid derivatives of aminopropanols did not exhibit any significant antioxidant or antiradical activity as evidenced by Fe(II)-stimulated ascorbate-dependent peroxidation, by spectrophotometric monitoring of a decrease in the concentration of stable 2,2-diphenyl-1-picrylhydrazyl radical, or by photochemiluminescence techniques. However, these compounds revealed a membrane-stabilizing effect preventing hemolytic destruction of cells under conditions of H₂O₂-stimulated oxidative stress of erythrocytes. In this respect, derivatives of glycine, leucine, and methionine were most interesting.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0481-y