The Survey of Diastolic Function Changes in End-Stage Renal Disease Patients Before and 3 and 6 Months After Kidney Transplantation

• Published in: Transplantation proceedings 2012-12, Vol.44 (10), p.3007-3012
• Main Authors: Salari, A, Monfared, A, Fahim, S.H.S.N, Khosravi, M, Lebadi, M, Mokhtari, G, Pourreza, F, Shakiba, M
• Format: Article
• Language: English
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Blood Pressure; Cross-Sectional Studies; Diastole; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Hypertrophy, Left Ventricular - diagnosis; Hypertrophy, Left Ventricular - epidemiology; Hypertrophy, Left Ventricular - physiopathology; Iran - epidemiology; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - surgery; Kidney Transplantation; Longitudinal Studies; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Prospective Studies; Recovery of Function; Renal failure; Stroke Volume; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Systole; Time Factors; Tissue, organ and graft immunology; Treatment Outcome; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - epidemiology; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2012.03.060

Abstract Introduction Left ventricular diastolic dysfunction, which is prevalent in end-stage renal disease, predicts morbidity and mortality among affected patients. The aim of this study was to evaluate diastolic function changes in end-stage renal disease patients before as well as 3 and 6 months after kidney transplantation. Methods and materials This longitudinal study from November 2008 to November 2009, enrolled 27 consecutive kidney transplant patients. Systolic and diastolic blood pressures and echocardiograghic parameters such as ejection fraction, left ventricular mass, and diastolic functions were measured before, as well as 3 and 6 months after transplantation. Data were analyzed by repeated-measure analysis of variance and Friedman tests using SPSS version 18. Results The mean patients age was 39.47 ± 12.27 years with 55.6% males. The mean systolic and diastolic blood pressure and left ventricular mass decreased significantly in the first 3 (125.44 ± 11.35, 78.51 ± 6.32, 141.94 ± 3.32) and 6 months (121.48 ± 10.63, 72.96 ± 4.21, 138.25 ± 3.12) after renal transplantation compared to the values before the procedure (136.77 ± 14.09, 81.92 ± 9.01, 158.30 ± 3.58 respectively; P < .05). The left ventricular ejection fraction increased significantly at 3 (63.00 ± 6.49) and 6 months (66.11 ± 5.87) compared with preoperative (62.48 ± 5.74; P < .05). Step mean diastolic function also decreased significantly at 3 (1.94) and 6 months (1.81) compared with before transplantation (2.24; P < .05). Conclusion According to our findings, transplantation can correct ejection fraction and systolic and diastolic blood pressure and lead to regression of left ventricular hypertrophy. Diastolic function was improved after transplantation.