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The ABCs of plasmid replication and segregation
RepABC family plasmids are found exclusively in alphaproteobacteria. The replication and partitioning proteins of these plasmids are encoded by a single operon, the repABC cassette. Here, Pinto, Pappas and Winans review the regulation of RepABC plasmid replication and partitioning, including the mec...
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| Published in: | Nature reviews. Microbiology 2012-11, Vol.10 (11), p.755-765 |
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| container_end_page | 765 |
| container_issue | 11 |
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| container_title | Nature reviews. Microbiology |
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| creator | Pinto, Uelinton M. Pappas, Katherine M. Winans, Stephen C. |
| description | RepABC family plasmids are found exclusively in alphaproteobacteria. The replication and partitioning proteins of these plasmids are encoded by a single operon, the
repABC
cassette. Here, Pinto, Pappas and Winans review the regulation of RepABC plasmid replication and partitioning, including the mechanisms that allow plasmid copynumber to be increased in response to external cues.
To ensure faithful transmission of low-copy plasmids to daughter cells, these plasmids must replicate once per cell cycle and distribute the replicated DNA to the nascent daughter cells. RepABC family plasmids are found exclusively in alphaproteobacteria and carry a combined replication and partitioning locus, the
repABC
cassette, which is also found on secondary chromosomes in this group. RepC and a replication origin are essential for plasmid replication, and RepA, RepB and the partitioning sites distribute the replicons to predivisional cells. Here, we review our current understanding of the transcriptional and post-transcriptional regulation of the Rep proteins and of their functions in plasmid replication and partitioning. |
| doi_str_mv | 10.1038/nrmicro2882 |
| format | article |
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repABC
cassette. Here, Pinto, Pappas and Winans review the regulation of RepABC plasmid replication and partitioning, including the mechanisms that allow plasmid copynumber to be increased in response to external cues.
To ensure faithful transmission of low-copy plasmids to daughter cells, these plasmids must replicate once per cell cycle and distribute the replicated DNA to the nascent daughter cells. RepABC family plasmids are found exclusively in alphaproteobacteria and carry a combined replication and partitioning locus, the
repABC
cassette, which is also found on secondary chromosomes in this group. RepC and a replication origin are essential for plasmid replication, and RepA, RepB and the partitioning sites distribute the replicons to predivisional cells. Here, we review our current understanding of the transcriptional and post-transcriptional regulation of the Rep proteins and of their functions in plasmid replication and partitioning.</description><identifier>ISSN: 1740-1526</identifier><identifier>EISSN: 1740-1534</identifier><identifier>DOI: 10.1038/nrmicro2882</identifier><identifier>PMID: 23070556</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>41 ; 631/208/726/2102 ; 631/326/41/2482 ; 631/337/151 ; Alphaproteobacteria - genetics ; Alphaproteobacteria - growth & development ; Bacteria ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Biomedical and Life Sciences ; Cell cycle ; Cell Division ; Chromosomes ; Cytogenetics ; Deoxyribonucleic acid ; DNA ; DNA Methylation ; DNA Replication ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Genetic aspects ; Genomics ; Infectious Diseases ; Life Sciences ; Medical Microbiology ; Microbiology ; Parasitology ; Physiological aspects ; Physiology ; Plasmids ; Plasmids - genetics ; Proteins ; review-article ; Symbiosis ; Transcription, Genetic ; Virology</subject><ispartof>Nature reviews. Microbiology, 2012-11, Vol.10 (11), p.755-765</ispartof><rights>Springer Nature Limited 2012</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-ccb9a2c0b9f42f925aff0322e1419c6847a6804b8a6652a9e39199e4ef2c5dae3</citedby><cites>FETCH-LOGICAL-c520t-ccb9a2c0b9f42f925aff0322e1419c6847a6804b8a6652a9e39199e4ef2c5dae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23070556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinto, Uelinton M.</creatorcontrib><creatorcontrib>Pappas, Katherine M.</creatorcontrib><creatorcontrib>Winans, Stephen C.</creatorcontrib><title>The ABCs of plasmid replication and segregation</title><title>Nature reviews. Microbiology</title><addtitle>Nat Rev Microbiol</addtitle><addtitle>Nat Rev Microbiol</addtitle><description>RepABC family plasmids are found exclusively in alphaproteobacteria. The replication and partitioning proteins of these plasmids are encoded by a single operon, the
repABC
cassette. Here, Pinto, Pappas and Winans review the regulation of RepABC plasmid replication and partitioning, including the mechanisms that allow plasmid copynumber to be increased in response to external cues.
To ensure faithful transmission of low-copy plasmids to daughter cells, these plasmids must replicate once per cell cycle and distribute the replicated DNA to the nascent daughter cells. RepABC family plasmids are found exclusively in alphaproteobacteria and carry a combined replication and partitioning locus, the
repABC
cassette, which is also found on secondary chromosomes in this group. RepC and a replication origin are essential for plasmid replication, and RepA, RepB and the partitioning sites distribute the replicons to predivisional cells. Here, we review our current understanding of the transcriptional and post-transcriptional regulation of the Rep proteins and of their functions in plasmid replication and partitioning.</description><subject>41</subject><subject>631/208/726/2102</subject><subject>631/326/41/2482</subject><subject>631/337/151</subject><subject>Alphaproteobacteria - genetics</subject><subject>Alphaproteobacteria - growth & development</subject><subject>Bacteria</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Cell cycle</subject><subject>Cell Division</subject><subject>Chromosomes</subject><subject>Cytogenetics</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>DNA Replication</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Genetic aspects</subject><subject>Genomics</subject><subject>Infectious Diseases</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Parasitology</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Plasmids</subject><subject>Plasmids - genetics</subject><subject>Proteins</subject><subject>review-article</subject><subject>Symbiosis</subject><subject>Transcription, Genetic</subject><subject>Virology</subject><issn>1740-1526</issn><issn>1740-1534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkUtLAzEURoMotlZX7mXAjaBtk5tJZrKsxRcU3NT1kGZu6pR51KRd-O9NH9YqBckir3O_5HIIuWS0xyhP-7WrCuMaSFM4Im2WxLTLBI-Pd2uQLXLm_YxSECKBU9ICThMqhGyT_vgdo8H90EeNjeal9lWRRw7nZWH0omjqSNd55HHqcLren5MTq0uPF9u5Q94eH8bD5-7o9ellOBh1jQC66BozURoMnSgbg1UgtLWUAyCLmTIyjRMtUxpPUi2lAK2QK6YUxmjBiFwj75CbTe7cNR9L9IusKrzBstQ1NkufMQDGYpkK8T_KGMgkEZQF9PoPOmuWrg6NrCmeUir4DzXVJWZFbZuF02YVmg04DW8qyVWgegeoMHIMPpoabRHOfxXcbgqCLO8d2mzuikq7z4zRbGUy2zMZ6KvtV5eTCvMd-60uAHcbwIereopur5cDeV_m7qUx</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Pinto, Uelinton M.</creator><creator>Pappas, Katherine M.</creator><creator>Winans, Stephen C.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>The ABCs of plasmid replication and segregation</title><author>Pinto, Uelinton M. ; Pappas, Katherine M. ; Winans, Stephen C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-ccb9a2c0b9f42f925aff0322e1419c6847a6804b8a6652a9e39199e4ef2c5dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>41</topic><topic>631/208/726/2102</topic><topic>631/326/41/2482</topic><topic>631/337/151</topic><topic>Alphaproteobacteria - genetics</topic><topic>Alphaproteobacteria - growth & development</topic><topic>Bacteria</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Cell cycle</topic><topic>Cell Division</topic><topic>Chromosomes</topic><topic>Cytogenetics</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>DNA Replication</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Genetic aspects</topic><topic>Genomics</topic><topic>Infectious Diseases</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Parasitology</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Plasmids</topic><topic>Plasmids - genetics</topic><topic>Proteins</topic><topic>review-article</topic><topic>Symbiosis</topic><topic>Transcription, Genetic</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinto, Uelinton M.</creatorcontrib><creatorcontrib>Pappas, Katherine M.</creatorcontrib><creatorcontrib>Winans, Stephen C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinto, Uelinton M.</au><au>Pappas, Katherine M.</au><au>Winans, Stephen C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ABCs of plasmid replication and segregation</atitle><jtitle>Nature reviews. Microbiology</jtitle><stitle>Nat Rev Microbiol</stitle><addtitle>Nat Rev Microbiol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>10</volume><issue>11</issue><spage>755</spage><epage>765</epage><pages>755-765</pages><issn>1740-1526</issn><eissn>1740-1534</eissn><abstract>RepABC family plasmids are found exclusively in alphaproteobacteria. The replication and partitioning proteins of these plasmids are encoded by a single operon, the
repABC
cassette. Here, Pinto, Pappas and Winans review the regulation of RepABC plasmid replication and partitioning, including the mechanisms that allow plasmid copynumber to be increased in response to external cues.
To ensure faithful transmission of low-copy plasmids to daughter cells, these plasmids must replicate once per cell cycle and distribute the replicated DNA to the nascent daughter cells. RepABC family plasmids are found exclusively in alphaproteobacteria and carry a combined replication and partitioning locus, the
repABC
cassette, which is also found on secondary chromosomes in this group. RepC and a replication origin are essential for plasmid replication, and RepA, RepB and the partitioning sites distribute the replicons to predivisional cells. Here, we review our current understanding of the transcriptional and post-transcriptional regulation of the Rep proteins and of their functions in plasmid replication and partitioning.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23070556</pmid><doi>10.1038/nrmicro2882</doi><tpages>11</tpages></addata></record> |
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| subjects | 41 631/208/726/2102 631/326/41/2482 631/337/151 Alphaproteobacteria - genetics Alphaproteobacteria - growth & development Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biomedical and Life Sciences Cell cycle Cell Division Chromosomes Cytogenetics Deoxyribonucleic acid DNA DNA Methylation DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genetic aspects Genomics Infectious Diseases Life Sciences Medical Microbiology Microbiology Parasitology Physiological aspects Physiology Plasmids Plasmids - genetics Proteins review-article Symbiosis Transcription, Genetic Virology |
| title | The ABCs of plasmid replication and segregation |
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