Inflammatory fatigue and sickness behaviour — Lessons for the diagnosis and management of chronic fatigue syndrome

Abstract Persistent and severe fatigue is a common part of the presentation of a diverse range of disease processes. There is a growing body of evidence indicating a common inflammatory pathophysiology underlying many conditions where fatigue is a primary patient concern, including chronic fatigue s...

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Bibliographic Details
Published in:Journal of affective disorders 2012-12, Vol.141 (2), p.130-142
Main Authors: Arnett, S.V, Clark, I.A
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Autoimmune Diseases - complications
Autoimmune disorders
Biological and medical sciences
Biomarker
Central nervous system
Chronic fatigue syndrome
Cytokine
Cytokines - physiology
Diagnosis
Fatigue
Fatigue - diagnosis
Fatigue - immunology
Fatigue - physiopathology
Fatigue Syndrome, Chronic - diagnosis
Fatigue Syndrome, Chronic - immunology
Fatigue Syndrome, Chronic - physiopathology
Humans
Illness Behavior - physiology
Inflammation Mediators - physiology
Medical sciences
Mood disorders
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Sickness behaviour
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Summary:Abstract Persistent and severe fatigue is a common part of the presentation of a diverse range of disease processes. There is a growing body of evidence indicating a common inflammatory pathophysiology underlying many conditions where fatigue is a primary patient concern, including chronic fatigue syndrome. This review explores current models of how inflammatory mediators act on the central nervous system to produce fatigue and sickness behaviour, and the commonality of these processes in conditions as diverse as surgical trauma, infection, various cancers, inflammatory bowel disease, connective tissue diseases and autoimmune diseases. We also discuss evidence indicating chronic fatigue syndrome may have important pathophysiological similarities with cytokine mediated sickness behaviour, and what lessons can be applied from sickness behaviour to chronic fatigue syndrome with regards to the diagnosis and management.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2012.04.004