Age-Related Alterations in Cardiac Geometry in Formerly Preeclamptic Women and Healthy Parous Controls: An Explorative Study

Introduction: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. Objective...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2013-01, Vol.20 (1), p.39-44
Main Authors: Ghossein-Doha, Chahinda, van Kuijk, Sander M. J., Spaanderman, Marc E. A., Delhaas, Tammo, Peeters, Louis L. H.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Embryology
Female
Follow-Up Studies
Heart Ventricles - diagnostic imaging
Hemodynamics - physiology
Humans
Longitudinal Studies
Medicine & Public Health
Middle Aged
Obstetrics/Perinatology/Midwifery
Original Articles
Parity - physiology
Postpartum Period - physiology
Pre-Eclampsia - diagnostic imaging
Pre-Eclampsia - epidemiology
Pregnancy
Reproductive Medicine
Ultrasonography
Ventricular Function, Left - physiology
Ventricular Remodeling - physiology
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Summary:Introduction: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. Objective: To explore the age-related changes in cardiovascular structure and function in formerly preeclamptic women relative to parous controls. Methods: A total of 20 formerly preeclamptic women and 8 parous controls underwent 2 echocardiograms at 1 and 14 years of postpartum. With the nonparametric Mann-Whitney U test and the Wilcoxon Signed Ranks test, we analyzed the between-group differences in cardiac structure and function at both time points and the time-related changes in these indices. Results: Left ventricular geometry and dimensions and systolic function were comparable in the 2 study groups at both time points. The age-related decline in E/A ratio and increase in intraventricular septum thickness were noted in both groups over time, without appreciable differences between groups. Conclusion: A history of preeclampsia does not affect the age-related cardiac remodeling over a period of 14 years.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719112459230