Adaptive response in the antioxidant defence system in the course and outcome in first-episode schizophrenia patients: A 12-months follow-up study

Abstract Correlation of plasma antioxidant enzyme activity with the course and outcome in first-episode schizophrenia patients ( n =49) was analyzed in order to assess the possible utility of peripheral markers of oxidative stress as prognostic factors. These markers were measured shortly after the...

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Bibliographic Details
Published in:Psychiatry research 2012-12, Vol.200 (2), p.218-222
Main Authors: Ruiz-Litago, Fátima, Seco, Jesús, Echevarría, Enrique, Martínez-Cengotitabengoa, Mónica, Gil, Javier, Irazusta, Jon, González-Pinto, Ana María
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Antioxidants
Biological and medical sciences
Biomarkers - blood
Catalase - blood
Female
First psychotic episode
Follow-Up Studies
Glutathione - blood
Glutathione Peroxidase - blood
Humans
Male
Medical sciences
Middle Aged
Oxidative Stress
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - blood
Superoxide Dismutase - blood
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Summary:Abstract Correlation of plasma antioxidant enzyme activity with the course and outcome in first-episode schizophrenia patients ( n =49) was analyzed in order to assess the possible utility of peripheral markers of oxidative stress as prognostic factors. These markers were measured shortly after the onset of schizophrenia, and again 1, 6 and 12 months later. A decrease in catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), and glutathione (GSH) levels and total antioxidant status (TAS), as well as an increase in thiobarbituric acid reactive substances (TBARS), were observed 1 month after ( p
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2012.07.024