Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides

Hericium erinaceus polysaccharide (HEP) is a traditional Chinese medicine. In the present study, chemical composition and antioxidant activity of HEP was investigated. HPLC analysis showed that the HEP was composed of xylose (7.8%), ribose (2.7%), glucose (68.4%), arabinose (11.3%), galactose (2.5%)...

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Bibliographic Details
Published in:International journal of biological macromolecules 2013-01, Vol.52, p.66-71
Main Authors: Han, Zi-Hua, Ye, Jian-Min, Wang, Guan-Fu
Format: Article
Language:English
Subjects:
Animals
Antioxidant
antioxidant activity
antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
arabinose
Basidiomycota - chemistry
blood serum
creatinine
Creatinine - blood
Drug Evaluation, Preclinical
enzymes
Fungal Polysaccharides - chemistry
Fungal Polysaccharides - pharmacology
galactose
glucose
glutathione
Hericium
Hericium erinaceus polysaccharides
high performance liquid chromatography
HPLC
in vivo studies
ischemia
Ischemia reperfusion
Kidney
Kidney - metabolism
Kidney - pathology
laboratory animals
lipid peroxidation
malondialdehyde
Malondialdehyde - blood
mannose
Mice
Oriental traditional medicine
polysaccharides
Rats
Rats, Wistar
Reperfusion Injury - blood
Reperfusion Injury - drug therapy
Reperfusion Injury - pathology
ribose
SOD
Urea - blood
urea nitrogen
xylose
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Summary:Hericium erinaceus polysaccharide (HEP) is a traditional Chinese medicine. In the present study, chemical composition and antioxidant activity of HEP was investigated. HPLC analysis showed that the HEP was composed of xylose (7.8%), ribose (2.7%), glucose (68.4%), arabinose (11.3%), galactose (2.5%) and mannose (5.2%). HEP was pre-administered to mice by gavage at a dose of 300mg/kg for 15 days. Results found that HEP preadministration resulted in a significant decline in blood urea nitrogen (BUN), serum creatinine (Scr) and increase in creatinine clearance (CrCI) levels in HEP-pretreated group compared to renal ischemia reperfusion (IR) group. Malondialdehyde (MDA) level significantly increased, whereas Level of reduced glutathione (GSH) markedly decreased in renal IR animals. These results indicate that IR induced renal oxidative injury damage, as indicated by a increase in MDA level, and decrease in GSH level as well as the antioxidant enzymes activity. Such effects reflect that HEP can significantly decrease lipid peroxidation level and increase antioxidant enzymes activities in experimental animals.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2012.09.009