Remarkable response to photodynamic therapy in residual T4N0M0 nasopharyngeal carcinoma: A case report

Summary Local treatment of residual or recurrent nasopharyngeal carcinoma (NPC) is a challenge. Photodynamic therapy (PDT) is an established treatment modality for incurable head and neck carcinoma. Several studies reported induction of an immune response after PDT. We present a patient with residua...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2012-12, Vol.9 (4), p.319-320
Main Authors: Indrasari, S.R, Timmermans, A.J, Wildeman, M.A, Karakullukcu, M.B, Herdini, C, Hariwiyanto, B, Tan, I.B., MD PhD
Format: Article
Language:English
Subjects:
Adult
Carcinoma
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Male
Mesoporphyrins - therapeutic use
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - drug therapy
Neoadjuvant Therapy
Neoplasm, Residual - therapy
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Residual disease
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Summary:Summary Local treatment of residual or recurrent nasopharyngeal carcinoma (NPC) is a challenge. Photodynamic therapy (PDT) is an established treatment modality for incurable head and neck carcinoma. Several studies reported induction of an immune response after PDT. We present a patient with residual T4N0M0 NPC who was treated with PDT for residual disease after initial treatment with neo-adjuvant chemotherapy and radiotherapy. Five years after PDT, the tumor did not progress and the patient is still in good condition. We discuss this remarkable long-term response to PDT and speculate on possible mechanisms.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2012.06.005