Oxidative stress programming in a rat model of postnatal early overnutrition — role of insulin resistance

• Published in: The Journal of nutritional biochemistry 2013, Vol.24 (1), p.81-87
• Main Authors: Conceição, Ellen P.S, Franco, Juliana G, Oliveira, Elaine, Resende, Angela C, Amaral, Taline A.S, Peixoto-Silva, Nayara, Passos, Magna C.F, Moura, Egberto G, Lisboa, Patrícia C
• Format: Article
• Language: English
• Subjects: adulthood; adults; animal models; Animals; Animals, Newborn - metabolism; Body Weight; catalase; Catalase - metabolism; cytoplasm; diabetes; Eating; Female; food intake; glutathione peroxidase; Glutathione Peroxidase - metabolism; human diseases; insulin; Insulin - metabolism; Insulin Resistance; Intra-Abdominal Fat - growth & development; Intra-Abdominal Fat - metabolism; Litter Size; liver; Liver - growth & development; Liver - metabolism; Liver - pathology; Nitrites - metabolism; obesity; overfeeding; Overnutrition - metabolism; Oxidative Stress; progeny; protein synthesis; Proto-Oncogene Proteins c-akt - metabolism; pups; Rats; Rats, Wistar; superoxide dismutase; Superoxide Dismutase - metabolism; visceral fat; weaning; zinc
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/j.jnutbio.2012.02.010

Postnatal early overfeeding (EO) is related to later development of overweight and other metabolic disorders. As oxidative stress is implicated in most human diseases, as obesity and diabetes, we decided to study some parameters related to oxidative stress and insulin signaling in liver from EO animals in adult life. To induce EO, litter size was reduced to three pups per litter (SL: small litter) and groups with normal litter size (NL:10 pups per litter) were used as control. After weaning, rats had free access to standard diet and water. Body weight and food intake were monitored daily and offspring were killed at 180 days-old. Significant differences had P