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The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins

Abstract Background and aim Sulfur amino acids are recognized as potent modulators of lipid metabolism. Plasma total cysteine (tCys) is associated with fat mass, obesity and serum LDL-cholesterol and apolipoprotein (Apo)-B in large population studies. It is not known how fasting plasma concentration...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2012-12, Vol.22 (12), p.1031-1038
Main Authors: Elshorbagy, A.K, Valdivia-Garcia, M, Graham, I.M, Palma Reis, R, Sales Luis, A, Smith, A.D, Refsum, H
Format: Article
Language:English
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Summary:Abstract Background and aim Sulfur amino acids are recognized as potent modulators of lipid metabolism. Plasma total cysteine (tCys) is associated with fat mass, obesity and serum LDL-cholesterol and apolipoprotein (Apo)-B in large population studies. It is not known how fasting plasma concentrations of cysteine precursors and products relate to these associations in humans, given that sulfur-containing compounds (SCC) influence rodent weight gain and serum lipids. Methods and results We investigated the cross-sectional associations of fasting plasma SCC (methionine, total homocysteine, cystathionine, tCys, taurine and total glutathione) with BMI and fasting serum lipids and apolipoproteins in 854 men and women with and without cardiovascular disease (CVD). In multiple linear regression analysis adjusted for age, gender, CVD and other SCC, neither methionine, taurine, nor total glutathione was associated with BMI. Plasma taurine was, however, inversely related to HDL-cholesterol (partial r  = −0.12, p  = 0.004) and its associated apoA1 (partial r  = −0.18, p  
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2011.01.008