Investigation of the relationship between serum creatine kinase and genetic polymorphisms in military recruits

Genetic polymorphisms may explain why certain individuals will develop exertional rhabdomyolysis (ER) or markedly elevated serum creatine kinase (CK) levels following exertion, while others in the same environment, performing the same exertion, do not. Prospectively, 499 recruits were evaluated duri...

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Bibliographic Details
Published in:Military medicine 2012-11, Vol.177 (11), p.1359-1365
Main Authors: Landau, Mark E, Kenney, Kimbra, Deuster, Patricia, Gonzalez, Rodney S, Contreras-Sesvold, Carmen, Sambuughin, Nyamkhishig, O'Connor, Francis G, Campbell, William W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Chemokines
Creatine Kinase - blood
Cytokines
Deoxyribonucleic acid
DNA
DNA - analysis
Enzymes
Female
Genes
Genetic testing
Genetic Testing - methods
Genotype & phenotype
Humans
Hyperthermia
Illnesses
Interleukin-6 - genetics
Kinases
Male
Middle Aged
Military Personnel
Mutation
Physical Exertion - physiology
Polymorphism
Polymorphism, Genetic
Prospective Studies
Reference Values
Rhabdomyolysis
Rhabdomyolysis - enzymology
Rhabdomyolysis - etiology
Rhabdomyolysis - genetics
Young Adult
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Summary:Genetic polymorphisms may explain why certain individuals will develop exertional rhabdomyolysis (ER) or markedly elevated serum creatine kinase (CK) levels following exertion, while others in the same environment, performing the same exertion, do not. Prospectively, 499 recruits were evaluated during the initial fortnight of Army basic training. Serum CK levels were determined before and during that time. Eleven candidate genetic polymorphisms were studied and compared to CK levels. No subjects developed ER. Baseline CK was significantly greater in interleukin-6 G174C GG and myosin light chain kinase 2 (MLCK 2) AA subjects. Intertraining levels were significantly greater in angiotensin I-converting enzyme D/D and interleukin-6 GG subjects. Among African-Americans, those with MLCK2 AA had greater baseline CK (1,352 +/- 1,102.8 IU/L) than AC and CC genotypes (536.9 +/- 500.6). African-American men have the highest baseline levels and are more likely to have MLCK AA genotype. Whether this finding is associated with an increased incidence of ER requires further study.
ISSN:0026-4075
1930-613X
DOI:10.7205/MILMED-D-12-00086