Effect of pH and temperature on the morphology and phases of co-precipitated hydroxyapatite

This paper reports a high-yield process to fabricate biomimetic hydroxyapatite nano-particles or nano-plates. Hydroxyapatite is obtained by simultaneous dripping of calcium chloride and ammonium hydrogen phosphate solutions into a reaction vessel. Reactions were carried out under various pH and temp...

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Bibliographic Details
Published in:Journal of sol-gel science and technology 2012-03, Vol.61 (3), p.592-599
Main Authors: Le, H. R., Chen, K. Y., Wang, C. A.
Format: Article
Language:English
Subjects:
Biomedical materials
Biomimetics
Blood vessels
Bone cements
Calcium chloride
Ceramics
Chemical precipitation
Chemistry
Chemistry and Materials Science
Colloidal gels. Colloidal sols
Colloidal state and disperse state
Composites
Crystal growth
Exact sciences and technology
General and physical chemistry
Glass
Hydroxyapatite
Inorganic Chemistry
Materials Science
Morphology
Nacre
Nanoparticles
Nanotechnology
Natural Materials
Optical and Electronic Materials
Original Paper
Phase composition
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Plates
Precipitates
Surgical implants
X-ray diffraction
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Summary:This paper reports a high-yield process to fabricate biomimetic hydroxyapatite nano-particles or nano-plates. Hydroxyapatite is obtained by simultaneous dripping of calcium chloride and ammonium hydrogen phosphate solutions into a reaction vessel. Reactions were carried out under various pH and temperature conditions. The morphology and phase composition of the precipitates were investigated using scanning electron microscope and X-ray diffraction. The analyses showed that large plates of calcium hydrophosphate are formed at neutral or acidic pH condition. Nanoparticles of hydroxyapatite were obtained in precipitates prepared at pH 9–11. Hydroxyapatite plates akin to seashell nacre were obtained at 40 °C and pH 9. This material holds promise to improve the strength of hydroxyapatite containing composites for bone implant or bone cement used in orthopaedic surgeries. The thermodynamics of the crystal growth under these conditions was discussed. An assembly mechanism of the hydroxyapatite plates was proposed according to the nanostructure observations.
ISSN:0928-0707
1573-4846
DOI:10.1007/s10971-011-2665-7