Enantioselective organocatalytic formal allylation of [small alpha]-branched aldehydes

Heteroarylvinyl sulfone 1 has been successfully used as a new sulfonyl Michael acceptor in aminocatalytic reactions with branched aldehydes. Subsequent one-pot Julia-Kocienski olefination allows the challenging preparation of enantiomerically pure [small alpha]-allylated aldehydes bearing C-[small a...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (40), p.11267-11269
Main Authors: Rodrigo, Eduardo, Morales, Sara, Duce, Sara, Ruano, Jose Luis Garcia, Cid, MBelen
Format: Article
Language:English
Subjects:
Aldehydes
Bearing
Branched
Carbon
Sulfones
Online Access:Get full text
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Summary:Heteroarylvinyl sulfone 1 has been successfully used as a new sulfonyl Michael acceptor in aminocatalytic reactions with branched aldehydes. Subsequent one-pot Julia-Kocienski olefination allows the challenging preparation of enantiomerically pure [small alpha]-allylated aldehydes bearing C-[small alpha] quaternary carbons.
ISSN:1359-7345
DOI:10.1039/C1CC14909A