A low-noise fully-differential CMOS preamplifier for neural recording applications

A fully-differential bandpass CMOS preamplifier for extracellular neural recording is presented in this paper. The capacitive-coupled and capacitive-feedback topology is adopted. We describe the main noise sources of the proposed preamplifier and discuss the methods for achieving the lowest input-re...

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Bibliographic Details
Published in:Science China. Information sciences 2012-02, Vol.55 (2), p.441-452
Main Authors: Zhang, Xu, Pei, WeiHua, Huang, BeiJu, Guan, Ning, Chen, HongDa
Format: Article
Language:English
Subjects:
CMOS
Computer Science
Energy dissipation
Information Systems and Communication Service
Recording
Research Paper
Topology
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Summary:A fully-differential bandpass CMOS preamplifier for extracellular neural recording is presented in this paper. The capacitive-coupled and capacitive-feedback topology is adopted. We describe the main noise sources of the proposed preamplifier and discuss the methods for achieving the lowest input-referred noise. The preamplifier has a midband gain of 43 dB and a DC gain of 0. The −3 dB upper cut-off frequency of the preamplifier is 6.8 kHz. The lower cut-off frequency can be adjusted for amplifying the field or action potentials located in different bands. It has an input-referred noise of 3.36 μVrms integrated from 1 Hz to 6.8 kHz for recording the local field potentials (LFPs) and the mixed neural spikes with a power dissipation of 24.75 μW from 3.3 V supply. When the passband is configured as 100 Hz-6.8 kHz for only recording spikes, the noise is measured to be 3.01 μVrms. The 0.115 mm 2 prototype chip is designed and fabricated in 0.35-μm N -well CMOS (complementary metal oxide semiconductor) 2P4M process.
ISSN:1674-733X
1869-1919
DOI:10.1007/s11432-011-4333-5