A novel and efficient method combining SFE and liquid–liquid extraction for separation of coumarins from Angelica dahurica

[Display omitted] ▶ SFE was used to extract coumarins from Angelica dahurica. ▶ RIC was calculated to judge the separation efficiency. ▶ Petroleum ether/water extraction was designed to remove low polar impurities. ▶ Petroleum ether/60% methanol extraction was designed to purify the coumarins. Nowad...

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Bibliographic Details
Published in:Separation and purification technology 2011-03, Vol.77 (3), p.397-401
Main Authors: Wang, Long-Hu, Mei, Yan-Hong, Wang, Feng, Liu, Xue-Song, Chen, Yong
Format: Article
Language:English
Subjects:
Angelica dahurica
Applied sciences
Biological and medical sciences
Chemical engineering
Coumarin
Coumarins
Crude oil
Economics
Ethers
Exact sciences and technology
Food engineering
Food industries
Fundamental and applied biological sciences. Psychology
General aspects
Liquid-liquid extraction
LLE
Methyl alcohol
Selectivity
Separation
SFE
Supercritical fluid extraction
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Summary:[Display omitted] ▶ SFE was used to extract coumarins from Angelica dahurica. ▶ RIC was calculated to judge the separation efficiency. ▶ Petroleum ether/water extraction was designed to remove low polar impurities. ▶ Petroleum ether/60% methanol extraction was designed to purify the coumarins. Nowadays supercritical fluid extraction (SFE) as an alternative is popular in food and pharmaceutical industries but its large scale application is often restricted economically by the confliction between recovery efficiency and selectivity. In this article, a simple but novel and efficient combined method was investigated for separating coumarins from Angelica dahurica. The experimental results showed that combining SFE and liquid–liquid extraction could improve both extraction selectivity and separation efficiency, enriching easily coumarins from 0.144% in the herb to as much as 41.68% in the concentrate.
ISSN:1383-5866
1873-3794
DOI:10.1016/j.seppur.2010.12.020