Fluorescent indicators based on BODIPY

This critical review covers the advances made using the 4-bora-3 a ,4 a -diaza- s -indacene (BODIPY) scaffold as a fluorophore in the design, synthesis and application of fluorescent indicators for pH, metal ions, anions, biomolecules, reactive oxygen species, reactive nitrogen species, redox potent...

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Bibliographic Details
Published in:Chemical Society reviews 2012-01, Vol.41 (3), p.113-1172
Main Authors: Boens, Nol, Leen, Volker, Dehaen, Wim
Format: Article
Language:English
Subjects:
Animals
Biomolecules
Boron Compounds - chemical synthesis
Boron Compounds - chemistry
Chemical Phenomena
Chemical reactions
Criteria
Drug Design
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorometers
Humans
Indicators
Mathematical analysis
Synthesis
Titration
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Summary:This critical review covers the advances made using the 4-bora-3 a ,4 a -diaza- s -indacene (BODIPY) scaffold as a fluorophore in the design, synthesis and application of fluorescent indicators for pH, metal ions, anions, biomolecules, reactive oxygen species, reactive nitrogen species, redox potential, chemical reactions and various physical phenomena. The sections of the review describing the criteria for rational design of fluorescent indicators and the mathematical expressions for analyzing spectrophotometric and fluorometric titrations are applicable to all fluorescent probes (206 references). This critical review covers the advances made using the 4-bora-3 a ,4 a -diaza- s -indacene (BODIPY) scaffold as a signaling unit in fluorescent indicators.
ISSN:0306-0012
1460-4744
DOI:10.1039/c1cs15132k