Dihydroxy-isosteviol-methyl-ester, an active biological component of Pulsatilla nigricans , reduces arsenic induced cellular dysfunction in testis of male mice

Graphical abstract Highlights ► Pulsatilla nigricans (PN) ameliorates arsenic-induced reproductive toxicity. ► PN administration reduces arsenic-induced DNA damage and apoptosis in testes. ► Possible signaling pathway to reduce reproductive toxicity by PN was determined.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2012-11, Vol.34 (3), p.743-752
Main Authors: Samadder, Asmita, Das, Jayeeta, Das, Sreemanti, Khuda-Bukhsh, Anisur Rahman
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Arsenic - toxicity
Diterpenes, Kaurane - pharmacology
Dose-Response Relationship, Drug
Emergency
Hazardous Substances - toxicity
Male
Mice
Mice, Inbred Strains
Oxidative stress
Oxidative Stress - drug effects
Plant Extracts - pharmacology
Pulsatilla
Pulsatilla nigricans
Reactive Oxygen Species - metabolism
Signal proteins
Sodium arsenite
Testis - drug effects
Testis - metabolism
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Description
Summary:Graphical abstract Highlights ► Pulsatilla nigricans (PN) ameliorates arsenic-induced reproductive toxicity. ► PN administration reduces arsenic-induced DNA damage and apoptosis in testes. ► Possible signaling pathway to reduce reproductive toxicity by PN was determined.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2012.09.013