Heart rate dynamics during acute pain in newborns

Autonomic nervous system modulation of heart rate is significantly altered during painful procedures in newborns. Most studies investigating pain employed only linear-based analysis methods, thus ignoring the complex, non-linear nature of heart rate control mechanisms. The emergences of dynamic, non...

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Bibliographic Details
Published in:Pflügers Archiv 2012-12, Vol.464 (6), p.593-599
Main Authors: Weissman, Amir, Zimmer, Etan Z., Aranovitch, Michal, Blazer, Shraga
Format: Article
Language:English
Subjects:
Acute Pain - physiopathology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Female
Heart Rate - physiology
Human Physiology
Humans
Infant, Newborn - physiology
Integrative Physiology
Male
Molecular Medicine
Neurosciences
Nonlinear Dynamics
Receptors
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Summary:Autonomic nervous system modulation of heart rate is significantly altered during painful procedures in newborns. Most studies investigating pain employed only linear-based analysis methods, thus ignoring the complex, non-linear nature of heart rate control mechanisms. The emergences of dynamic, nonlinear analysis methods enable us to uncover information embedded in the fluctuations of heart rate not otherwise noticeable. Our objective was to examine how cardiac dynamics change in newborns who undergo heel lancing by analyzing linear and nonlinear characteristics of heart rate fluctuations. We used dynamic nonlinear analyses methods to reveal heart rate variability and complexity alterations during painful stimulus in newborns. Poincaré plots were applied to examine the dynamics of the system, sample entropy to investigate the complexity of the system, and detrended fluctuation analysis, to reveal the fractal properties of the system. Heart rate significantly increased (165 vs.123 beats per minute, p  
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-012-1168-x