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Heart rate dynamics during acute pain in newborns
Autonomic nervous system modulation of heart rate is significantly altered during painful procedures in newborns. Most studies investigating pain employed only linear-based analysis methods, thus ignoring the complex, non-linear nature of heart rate control mechanisms. The emergences of dynamic, non...
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| Published in: | Pflügers Archiv 2012-12, Vol.464 (6), p.593-599 |
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| cites | cdi_FETCH-LOGICAL-c438t-8b76ed50218948e0ea7bea79980f4842cf34c5a9d6cce84b6d72f869b321a69a3 |
| container_end_page | 599 |
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| container_title | Pflügers Archiv |
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| creator | Weissman, Amir Zimmer, Etan Z. Aranovitch, Michal Blazer, Shraga |
| description | Autonomic nervous system modulation of heart rate is significantly altered during painful procedures in newborns. Most studies investigating pain employed only linear-based analysis methods, thus ignoring the complex, non-linear nature of heart rate control mechanisms. The emergences of dynamic, nonlinear analysis methods enable us to uncover information embedded in the fluctuations of heart rate not otherwise noticeable. Our objective was to examine how cardiac dynamics change in newborns who undergo heel lancing by analyzing linear and nonlinear characteristics of heart rate fluctuations. We used dynamic nonlinear analyses methods to reveal heart rate variability and complexity alterations during painful stimulus in newborns. Poincaré plots were applied to examine the dynamics of the system, sample entropy to investigate the complexity of the system, and detrended fluctuation analysis, to reveal the fractal properties of the system. Heart rate significantly increased (165 vs.123 beats per minute,
p
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| doi_str_mv | 10.1007/s00424-012-1168-x |
| format | article |
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p
< 0.001) while variability decreased. Sample entropy and the quantitative measures of the Poincaré plots (SD1 and SD2) significantly decreased during heel lancing (0.75 vs. 1.0,
p
< 0.01; 6.4 vs. 12.8,
p
< 0.001; and 30.4 vs. 50.5,
p
< 0.01, respectively). Detrended fluctuation analysis showed a significant decrease in the short-term scaling exponent α1 (1.06 vs. 1.3,
p
< 0.001), and an increase in the long-term scaling exponent α2 (1.5 vs. 1.1,
p
< 0.001). Our results indicate altered complexity of heart rate variability during painful stimulus in newborns and disruption of the mechanisms that regularly control it. Such alterations resemble certain pathological conditions and may represent stress reaction.]]></description><identifier>ISSN: 0031-6768</identifier><identifier>EISSN: 1432-2013</identifier><identifier>DOI: 10.1007/s00424-012-1168-x</identifier><identifier>PMID: 23053480</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acute Pain - physiopathology ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Female ; Heart Rate - physiology ; Human Physiology ; Humans ; Infant, Newborn - physiology ; Integrative Physiology ; Male ; Molecular Medicine ; Neurosciences ; Nonlinear Dynamics ; Receptors</subject><ispartof>Pflügers Archiv, 2012-12, Vol.464 (6), p.593-599</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-8b76ed50218948e0ea7bea79980f4842cf34c5a9d6cce84b6d72f869b321a69a3</citedby><cites>FETCH-LOGICAL-c438t-8b76ed50218948e0ea7bea79980f4842cf34c5a9d6cce84b6d72f869b321a69a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23053480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weissman, Amir</creatorcontrib><creatorcontrib>Zimmer, Etan Z.</creatorcontrib><creatorcontrib>Aranovitch, Michal</creatorcontrib><creatorcontrib>Blazer, Shraga</creatorcontrib><title>Heart rate dynamics during acute pain in newborns</title><title>Pflügers Archiv</title><addtitle>Pflugers Arch - Eur J Physiol</addtitle><addtitle>Pflugers Arch</addtitle><description><![CDATA[Autonomic nervous system modulation of heart rate is significantly altered during painful procedures in newborns. Most studies investigating pain employed only linear-based analysis methods, thus ignoring the complex, non-linear nature of heart rate control mechanisms. The emergences of dynamic, nonlinear analysis methods enable us to uncover information embedded in the fluctuations of heart rate not otherwise noticeable. Our objective was to examine how cardiac dynamics change in newborns who undergo heel lancing by analyzing linear and nonlinear characteristics of heart rate fluctuations. We used dynamic nonlinear analyses methods to reveal heart rate variability and complexity alterations during painful stimulus in newborns. Poincaré plots were applied to examine the dynamics of the system, sample entropy to investigate the complexity of the system, and detrended fluctuation analysis, to reveal the fractal properties of the system. Heart rate significantly increased (165 vs.123 beats per minute,
p
< 0.001) while variability decreased. Sample entropy and the quantitative measures of the Poincaré plots (SD1 and SD2) significantly decreased during heel lancing (0.75 vs. 1.0,
p
< 0.01; 6.4 vs. 12.8,
p
< 0.001; and 30.4 vs. 50.5,
p
< 0.01, respectively). Detrended fluctuation analysis showed a significant decrease in the short-term scaling exponent α1 (1.06 vs. 1.3,
p
< 0.001), and an increase in the long-term scaling exponent α2 (1.5 vs. 1.1,
p
< 0.001). Our results indicate altered complexity of heart rate variability during painful stimulus in newborns and disruption of the mechanisms that regularly control it. Such alterations resemble certain pathological conditions and may represent stress reaction.]]></description><subject>Acute Pain - physiopathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Infant, Newborn - physiology</subject><subject>Integrative Physiology</subject><subject>Male</subject><subject>Molecular Medicine</subject><subject>Neurosciences</subject><subject>Nonlinear Dynamics</subject><subject>Receptors</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuX6OSjaXqURV1hwYueQ5qm0mWb1qTF3X9vSlcRwTAhMDzzZngQuiRwSwCyuwDAKcdAKCZESLw7QnPCGcUUCDtGcwBGsMiEnKGzEDYAQLmkp2hGGaSMS5gjsrLa94nXvU3KvdNNbUJSDr5274k2Q-x2unZJLGc_i9a7cI5OKr0N9uLwLtDb48PrcoXXL0_Py_s1NpzJHssiE7ZMgRKZc2nB6qyIN88lVFxyairGTarzUhhjJS9EmdFKirxglGiRa7ZAN1Nu59uPwYZeNXUwdrvVzrZDUITGw5gEGdHrP-imHbyL20VKCB4XSmmkyEQZ34bgbaU6Xzfa7xUBNfpUk08VfarRp9rFmatD8lA0tvyZ-BYYAToBoRudWf_r639TvwB_5n54</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Weissman, Amir</creator><creator>Zimmer, Etan Z.</creator><creator>Aranovitch, Michal</creator><creator>Blazer, Shraga</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Heart rate dynamics during acute pain in newborns</title><author>Weissman, Amir ; Zimmer, Etan Z. ; Aranovitch, Michal ; Blazer, Shraga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-8b76ed50218948e0ea7bea79980f4842cf34c5a9d6cce84b6d72f869b321a69a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Pain - physiopathology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Infant, Newborn - physiology</topic><topic>Integrative Physiology</topic><topic>Male</topic><topic>Molecular Medicine</topic><topic>Neurosciences</topic><topic>Nonlinear Dynamics</topic><topic>Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weissman, Amir</creatorcontrib><creatorcontrib>Zimmer, Etan Z.</creatorcontrib><creatorcontrib>Aranovitch, Michal</creatorcontrib><creatorcontrib>Blazer, Shraga</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pflügers Archiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weissman, Amir</au><au>Zimmer, Etan Z.</au><au>Aranovitch, Michal</au><au>Blazer, Shraga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart rate dynamics during acute pain in newborns</atitle><jtitle>Pflügers Archiv</jtitle><stitle>Pflugers Arch - Eur J Physiol</stitle><addtitle>Pflugers Arch</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>464</volume><issue>6</issue><spage>593</spage><epage>599</epage><pages>593-599</pages><issn>0031-6768</issn><eissn>1432-2013</eissn><abstract><![CDATA[Autonomic nervous system modulation of heart rate is significantly altered during painful procedures in newborns. Most studies investigating pain employed only linear-based analysis methods, thus ignoring the complex, non-linear nature of heart rate control mechanisms. The emergences of dynamic, nonlinear analysis methods enable us to uncover information embedded in the fluctuations of heart rate not otherwise noticeable. Our objective was to examine how cardiac dynamics change in newborns who undergo heel lancing by analyzing linear and nonlinear characteristics of heart rate fluctuations. We used dynamic nonlinear analyses methods to reveal heart rate variability and complexity alterations during painful stimulus in newborns. Poincaré plots were applied to examine the dynamics of the system, sample entropy to investigate the complexity of the system, and detrended fluctuation analysis, to reveal the fractal properties of the system. Heart rate significantly increased (165 vs.123 beats per minute,
p
< 0.001) while variability decreased. Sample entropy and the quantitative measures of the Poincaré plots (SD1 and SD2) significantly decreased during heel lancing (0.75 vs. 1.0,
p
< 0.01; 6.4 vs. 12.8,
p
< 0.001; and 30.4 vs. 50.5,
p
< 0.01, respectively). Detrended fluctuation analysis showed a significant decrease in the short-term scaling exponent α1 (1.06 vs. 1.3,
p
< 0.001), and an increase in the long-term scaling exponent α2 (1.5 vs. 1.1,
p
< 0.001). Our results indicate altered complexity of heart rate variability during painful stimulus in newborns and disruption of the mechanisms that regularly control it. Such alterations resemble certain pathological conditions and may represent stress reaction.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23053480</pmid><doi>10.1007/s00424-012-1168-x</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| subjects | Acute Pain - physiopathology Biomedical and Life Sciences Biomedicine Cell Biology Female Heart Rate - physiology Human Physiology Humans Infant, Newborn - physiology Integrative Physiology Male Molecular Medicine Neurosciences Nonlinear Dynamics Receptors |
| title | Heart rate dynamics during acute pain in newborns |
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