Prognostic Significance of Circulating Tumor Cell Count in Patients With Metastatic Hormone-sensitive Prostate Cancer

Objective To analyze the correlation between circulating tumor cell (CTC) levels and clinicopathologic parameters (prostate-specific antigen level, Gleason score, and TNM stage) in patients with metastatic hormone-sensitive prostate cancer (PCa) and to establish its prognostic value in overall survi...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2012-12, Vol.80 (6), p.1328-1332
Main Authors: Resel Folkersma, Luis, San José Manso, Luis, Galante Romo, Isabel, Moreno Sierra, Jesüs, Olivier Gómez, Carlos
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Disease Progression
Gynecology. Andrology. Obstetrics
Humans
Immunomagnetic Separation
Kaplan-Meier Estimate
Male
Male genital diseases
Medical sciences
Middle Aged
Neoplasm Staging
Neoplastic Cells, Circulating
Nephrology. Urinary tract diseases
Prognosis
Prospective Studies
Prostatic Neoplasms - blood
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Prostatic Neoplasms - physiopathology
ROC Curve
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
Urology
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Summary:Objective To analyze the correlation between circulating tumor cell (CTC) levels and clinicopathologic parameters (prostate-specific antigen level, Gleason score, and TNM stage) in patients with metastatic hormone-sensitive prostate cancer (PCa) and to establish its prognostic value in overall survival (OS) and progression-free survival (PFS). Materials and Methods A prospective, 3-arm study was performed that included 30 patients with localized PCa; 30 patients with metastatic PCa, and 30 healthy volunteers. A single 7.5-mL peripheral blood sample was taken. The CTCs were isolated using an immunomagnetic method based on the CellSearch system. Kendall's tau and Spearman's rho coefficients of correlation were used. The multivariate Cox regression model addressed OS and PFS. Results The median follow-up was 42.9 months (interquartile range 27.14-49.5). A significant positive correlation was demonstrated between the CTC level and all tumor burden markers (prostate-specific antigen and T, N, and M stage; P  
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2012.09.001