Validation of the association between PSMA6 −8 C/G polymorphism and type 2 diabetes mellitus in Chinese Dongxiang and Han populations

Abstract Objective The aim of our study was to validate association between −8 C/G variant of PSMA6 gene and T2DM in Chinese Dongxiang and Han populations. Method We genotyped PSMA6 gene −8 C/G polymorphism in the control groups and T2DM groups in two populations from China using PCR-RFLP technique....

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Published in:Diabetes research and clinical practice 2012-11, Vol.98 (2), p.295-301
Main Authors: Liu, Jing, Yuan, Xin-jian, Liu, Ju-xiang, Tian, Li-min, Quan, Jin-xing, Liu, Jia, Chen, Xiao-hui, Wang, Yun-fang, Shi, Zhi-yong, Zhang, Jun-ling
Format: Article
Language:English
Subjects:
8 C/G polymorphism
Adult
Asian Continental Ancestry Group
China
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
Dongxiang population
Endocrinology & Metabolism
Female
Gene Frequency - genetics
Genetic Predisposition to Disease
Genotype
Han
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide - genetics
Population
Proteasome Endopeptidase Complex - genetics
PSMA6
Type 2 diabetes mellitus
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Summary:Abstract Objective The aim of our study was to validate association between −8 C/G variant of PSMA6 gene and T2DM in Chinese Dongxiang and Han populations. Method We genotyped PSMA6 gene −8 C/G polymorphism in the control groups and T2DM groups in two populations from China using PCR-RFLP technique. Phenotypes and biochemical indicators were measured by biochemical technique. Result The frequencies of CG + GG genotype were observably different from CC genotype in the T2DM groups and control groups (for Dongxiang population: OR = 1.341, 95% CI: 1.101–1.632, P = 0.004; for Han population: OR = 1.313, 95% CI: 1.085–1.569, P = 0.006 after adjusting for gender, age, and BMI, respectively). In the Dongxiang population, the FPG, HOMA-IR, SBP and TG levels of CG + GG genotype were markedly higher than those of the CC genotype in control group (all P < 0.05). However, in the Han population, we only found that the FPI level of the CC genotype was significantly higher than that of the CG + GG genotype in control group ( P < 0.05). Conclusion Our investigation suggests that −8 C/G variant of PSMA6 gene may be associated with T2DM and diabetes-related metabolic traits in Chinese Dongxiang and Han populations.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2012.09.021