Phytochemical composition and toxicity of an antioxidant extract from Pimpinella brachycarpa ( Kom. ) Nakai

Highlights ▸ An EtOAc soluble extract was isolated from Pimpinella brachycarpa ( Kom. ) Nakai. ▸ EtOAc soluble extract had antioxidant effect through scavenging of intracellular ROS. ▸ Moreover, five chemicals were firstly isolated from PBet. ▸ EtOAc soluble extract had no acute toxicity or genotoxi...

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Published in:Environmental toxicology and pharmacology 2012-09, Vol.34 (2), p.409-415
Main Authors: Lu, Jing, Qian, Wenhui, Xu, Linli, Huang, Guoren, Cong, Wen, Wang, Zhenning, Deng, Xuming, Wang, Dacheng, Guan, Shuang
Format: Article
Language:English
Subjects:
acute toxicity
Animals
antioxidant activity
Antioxidants - toxicity
beta-sitosterol
bone marrow
Cell Line, Tumor
Cell Survival - drug effects
chromosome aberrations
Emergency
erythrocytes
ethyl acetate
functional foods
green leafy vegetables
Humans
hydrogen peroxide
Mice
Mutagenicity Tests
myristic acid
Pimpinella
Plant Extracts - chemistry
Plant Extracts - toxicity
pregnenolone
Reactive Oxygen Species - metabolism
Sitosterols - analysis
Toxicity Tests, Acute
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Summary:Highlights ▸ An EtOAc soluble extract was isolated from Pimpinella brachycarpa ( Kom. ) Nakai. ▸ EtOAc soluble extract had antioxidant effect through scavenging of intracellular ROS. ▸ Moreover, five chemicals were firstly isolated from PBet. ▸ EtOAc soluble extract had no acute toxicity or genotoxicity.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2012.05.015