Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: Histopathological aspects

In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna™) to scars in a rabbit ear model of hypertrophic scarring, significant i...

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Bibliographic Details
Published in:Archives of pharmacal research 2012-11, Vol.35 (11), p.1999-2006
Main Authors: Lee, Dong Won, Ku, Sae Kwang, Cho, Hyuk Jun, Kim, Jeong Hwan, Hiep, Tran Tuan, Han, Sang Duk, Kim, Bo Gyun, Kang, Min Kyung, Do, Eui Seon, Jun, Joon Ho, Jang, Sun Woo, Son, Mi-Won, Sohn, Young Taek, Choi, Han-Gon, Yong, Chul Soon, Kim, Jong Oh
Format: Article
Language:English
Subjects:
Allantoin - administration & dosage
Allantoin - pharmacology
Animals
Cicatrix, Hypertrophic - drug therapy
Cicatrix, Hypertrophic - pathology
Disease Models, Animal
Drug Combinations
Female
Heparin - administration & dosage
Heparin - pharmacology
Medicine
Pantothenic Acid - administration & dosage
Pantothenic Acid - analogs & derivatives
Pantothenic Acid - pharmacology
Pharmacology/Toxicology
Pharmacy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Rabbits
Research Article
Silicone Gels - chemistry
Skin - drug effects
Skin - metabolism
Skin - pathology
Skin Pigmentation - drug effects
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Summary:In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna™) to scars in a rabbit ear model of hypertrophic scarring, significant improvements in hypertrophic scar healing and a great loss of skin pigment were observed compared to the non-treated control, base or silicone control-treated scars. Furthermore, histological analysis of Noscarna™-treated scars revealed a significant reduction in scar elevation index (SEI), anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts compared to all control hypertrophic scars. Furthermore, Noscarna™ showed more favorable effects on hypertrophic scars than a commercial product, Contractubex®. Therefore, these results clearly demonstrated that the newly developed silicone-based gel, Noscarna™, could be a promising formulation as an effective therapeutic agent for hypertrophic scars.
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-012-1117-4