Antiamnesic activity of Syzygium cumini against scopolamine induced spatial memory impairments in rats

Abstract We evaluated the Antiamnesic effects of methanolic extract of Syzygium cumini (MESC) on spatial memory impairments induced by scopolamine (1 mg/kg, i.p.), a muscarinic antagonist, using the Radial arm maze, Morris water maze, learned helpless ness tests. Effect of MESC was evaluated and com...

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Published in:Brain & development (Tokyo. 1979) 2012-11, Vol.34 (10), p.844-851
Main Authors: Alikatte, Kanaka Latha, Akondi, Butchi Raju, Yerragunta, Venu Gopal, Veerareddy, Prabhakar Reddy, Palle, Suresh
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Acetylcholinestrase
Animals
Antiamnestic compounds
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Learned helplessness test
Male
Maze Learning
Memory Disorders - chemically induced
Memory Disorders - drug therapy
Memory Disorders - enzymology
Morris water maze test
Myrtaceae - chemistry
Neurology
Oxidative stress
Piracetam
Plant Extracts - therapeutic use
Radial arm maze test
Rats
Rats, Wistar
Scopolamine Hydrobromide - toxicity
Syzygium cumini
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Summary:Abstract We evaluated the Antiamnesic effects of methanolic extract of Syzygium cumini (MESC) on spatial memory impairments induced by scopolamine (1 mg/kg, i.p.), a muscarinic antagonist, using the Radial arm maze, Morris water maze, learned helpless ness tests. Effect of MESC was evaluated and compared to standard drug, piracetam (200 mg/kg, i.p.). The MESC significantly ( p < 0.05) improved the impairment of short term or working memory induced by scopolamine in the Radial arm maze test, and significantly ( p < 0.05) reversed cognitive impairments in rats as measured by the learned helplessness test. In addition, MESC decreased escape latencies in the Morris water maze test. The activity of acetylcholinesterase in the brain was inhibited significantly ( p < 0.05) by treatment with MESC to a level similar to that observed in rats treated with piracetam. Moreover treatment with MESC (200 and 400 mg/kg, p.o.) to scopolamine induced rats significantly ( p < 0.05) decreased TBARS levels which was accompanied by an increase in the activities of SOD and Catalase. MESC has dose dependent effect and 400 mg/kg dose shown more prominent results when compared to 200 mg/kg dose of MESC . These results indicate that MESC may exert anti-amnesic activity via inhibition of acetylcholinesterase and antioxidant mechanisms in the brain.
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2012.02.008