HIV-1 RNA shedding in the female genital tract is associated with reduced quantity of Lactobacilli in clinically asymptomatic HIV-positive women

Abstract We quantified vaginal lactobacilli and determined their relationship with genital HIV-1 shedding and found a significant negative association between reduced quantity of lactobacilli and cervical HIV-1 viral load ( r2 = − 0.8900, P < 0.01), which may have implications of increased chance...

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Published in:Diagnostic microbiology and infectious disease 2013, Vol.75 (1), p.112-114
Main Authors: Mane, Arati, Kulkarni, Smita, Ghate, Manisha, Risbud, Arun, Thakar, Madhuri
Format: Article
Language:English
Subjects:
Adult
Asymptomatic Diseases
Bacterial Load
Cross-Sectional Studies
Female
Genital shedding
HIV Infections - virology
HIV-1
HIV-1 - genetics
Humans
Infectious Disease
Internal Medicine
Lactobacilli
Lactobacillus - isolation & purification
RNA, Viral - isolation & purification
Vagina - microbiology
Virus Shedding
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container_end_page 114
container_issue 1
container_start_page 112
container_title Diagnostic microbiology and infectious disease
container_volume 75
creator Mane, Arati
Kulkarni, Smita
Ghate, Manisha
Risbud, Arun
Thakar, Madhuri
description Abstract We quantified vaginal lactobacilli and determined their relationship with genital HIV-1 shedding and found a significant negative association between reduced quantity of lactobacilli and cervical HIV-1 viral load ( r2 = − 0.8900, P < 0.01), which may have implications of increased chances of sexual transmission of HIV-1 and genital infections.
doi_str_mv 10.1016/j.diagmicrobio.2012.09.009
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subjects Adult
Asymptomatic Diseases
Bacterial Load
Cross-Sectional Studies
Female
Genital shedding
HIV Infections - virology
HIV-1
HIV-1 - genetics
Humans
Infectious Disease
Internal Medicine
Lactobacilli
Lactobacillus - isolation & purification
RNA, Viral - isolation & purification
Vagina - microbiology
Virus Shedding
title HIV-1 RNA shedding in the female genital tract is associated with reduced quantity of Lactobacilli in clinically asymptomatic HIV-positive women
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