Cortical maturation in fetuses referred for 'isolated' mild ventriculomegaly: a longitudinal ultrasound assessment

ABSTRACT Objectives To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. Methods This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fe...

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Bibliographic Details
Published in:Prenatal diagnosis 2012-12, Vol.32 (13), p.1273-1281
Main Authors: Miguelote, R. F., Vides, B., Santos, R. F., Palha, J. A., Matias, A., Sousa, N.
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - embryology
Female
Fetal Development
Humans
Hydrocephalus - complications
Hydrocephalus - diagnostic imaging
Infant, Newborn
Magnetic Resonance Imaging
Male
Pregnancy
Pregnancy Outcome
Prospective Studies
Ultrasonography, Prenatal
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Summary:ABSTRACT Objectives To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. Methods This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the parieto‐occipital fissure (POF), calcarine fissure (CF) and sylvian fissure, and grading the Sylvian fissure operculization at 23–25, 27–28 and 31–32 weeks gestation were determined. Results At 23–25 and 27–28 gestational weeks, POF and CF mean depths were statistically lower in the IMV group. The POF and CF depth distribution had a normal distribution in the control group but displayed a bimodal distribution in the IMV group. IMV with progression of ventricular dilatation showed mean depth of CF lower than IMV in which ventriculomegaly regressed or remained stable. The sensitivity, specificity, positive predictive value and negative predictive value of a CF depth below the fifth percentile to predict progression of ventricular dilatation were, at 28 weeks, 100%, 88%, 67% and 100%, respectively. Conclusions Cortical fissure assessment by ultrasound allowed the differentiation of a subgroup of IMV fetuses with a higher risk of progression of ventricular dilatation. © 2012 John Wiley & Sons, Ltd.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.3992