Tissue-engineering repair of extrahepatic bile ducts

Abstract Background In recent years, with the widespread use of laparoscopic cholecystectomy and liver transplantation, complications involving the biliary system are increasing. All techniques available have a high risk of recurrence or high-morbidity problems. We developed a three-dimensional coll...

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Bibliographic Details
Published in:The Journal of surgical research 2013, Vol.179 (1), p.18-21
Main Authors: Pérez Alonso, Alejandro José, MD, PhD, Del Olmo Rivas, Carlos, MD, Romero, Ignacio Machado, MD, Cañizares Garcia, Francisco Javier, MD, PhD, Poyatos, Pablo Torne, MD, PhD
Format: Article
Language:English
Subjects:
Animals
Bile duct
Bile Duct Diseases - surgery
Bile Ducts, Extrahepatic - surgery
Biocompatible Materials
Cattle
Collagen
Gels
Guinea Pigs
Liver Diseases - surgery
Models, Animal
Repair
Sepharose
Surgery
Tissue engineering
Tissue Engineering - methods
Transplant
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Summary:Abstract Background In recent years, with the widespread use of laparoscopic cholecystectomy and liver transplantation, complications involving the biliary system are increasing. All techniques available have a high risk of recurrence or high-morbidity problems. We developed a three-dimensional collagen duct modified with agarose hydrogel, to substitute the affected extrahepatic bile duct. Materials and methods We used it in 40 guinea pigs and studied the histology and physiology at 4 wk, 3, and 6 mo after transplantation. Blood test, histologic techniques, and cholangiography were performed in all of them. Results All experimental animals survived up to their sacrifices. Our graft showed highly potential applications to treat hepatobiliary diseases that require surgery.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2012.08.035