Two-Stage Amplification of Receptors Using a Multilevel Orthogonal/Simultaneous Dynamic Combinatorial Library

Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2012-12, Vol.14 (23), p.5816-5819
Main Authors: Escalante, Andrea M, Orrillo, A. Gastón, Cabezudo, Ignacio, Furlan, Ricardo L. E
Format: Article
Language:English
Subjects:
Combinatorial Chemistry Techniques
Hydrazones - chemistry
Macrocyclic Compounds - chemistry
Molecular Conformation
Molecular Structure
Sulfur Compounds - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol3027335