Aspirin Use After Diagnosis Improves Survival in Older Adults with Colon Cancer: A Retrospective Cohort Study

Objectives To assess survival in relation to aspirin use after diagnosis in older adults with colon cancer. Design Subgroup analysis of a previously published cohort and retrospective study. Setting Individuals registered in the Eindhoven Cancer Registry (ECR) between 1998 and 2007, linked to prescr...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2012-12, Vol.60 (12), p.2232-2236
Main Authors: Reimers, Marlies S., Bastiaannet, Esther, van Herk-Sukel, Myrthe P. P., Lemmens, Valery E. P., van den Broek, Colette B. M., van de Velde, Cornelis J. H., de Craen, Anton J. M., Liefers, Gerrit Jan
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - therapeutic use
Biological and medical sciences
colon cancer
Colonic Neoplasms - diagnosis
Colonic Neoplasms - drug therapy
Colonic Neoplasms - mortality
Colorectal cancer
elderly
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Male
Medical sciences
Miscellaneous
Older people
Public health. Hygiene
Public health. Hygiene-occupational medicine
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
survival
Survival analysis
Survival Rate
Tumors
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Summary:Objectives To assess survival in relation to aspirin use after diagnosis in older adults with colon cancer. Design Subgroup analysis of a previously published cohort and retrospective study. Setting Individuals registered in the Eindhoven Cancer Registry (ECR) between 1998 and 2007, linked to prescriptions of low‐dose aspirin (80 mg) registered in a community pharmacy database. Participants Five hundred thirty‐six individuals aged 70 and older diagnosed with colon cancer with or without aspirin use after diagnosis. Measurements Survival was analyzed with user status as a time‐dependent covariate. Multivariate Poisson regression survival models were used to study the effect of aspirin on overall survival. Results One hundred seven participants (20.0%) started aspirin after being diagnosed with colon cancer; 429 (80.0%) were not prescribed aspirin. Three hundred thirty‐nine participants (63.2%) had died by the end of follow‐up. Aspirin use after diagnosis was associated with longer overall survival (rate ratio (RR) = 0.51, 95% confidence interval (CI) = 0.38–0.70, P 
ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.12033