Premature luteal regression in a pregnant mare and subsequent pregnancy maintenance with the use of oral altrenogest

Summary Premature luteal demise or luteal insufficiency is not well characterised as a cause of pregnancy loss in domestic species, including horses. In this report, a mare inseminated with cooled‐transported semen at our facility returned for a routine pregnancy diagnosis at 15 days post ovulation....

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Bibliographic Details
Published in:Equine veterinary journal 2013-01, Vol.45 (1), p.97-100
Main Authors: CANISSO, I. F., BELTAIRE, K. A., BEDFORD‐GUAUS, S. J.
Format: Article
Language:English
Subjects:
Abortion, Veterinary - prevention & control
Administration, Oral
altrenogest
Animals
Chorionic Gonadotropin - blood
Corpus Luteum Maintenance - drug effects
Estrone - analogs & derivatives
Estrone - blood
Female
high risk pregnancy
horse
luteal insufficiency
luteal regression
Pregnancy
pregnancy rescue
Progesterone - blood
Trenbolone Acetate - administration & dosage
Trenbolone Acetate - analogs & derivatives
Trenbolone Acetate - therapeutic use
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Summary:Summary Premature luteal demise or luteal insufficiency is not well characterised as a cause of pregnancy loss in domestic species, including horses. In this report, a mare inseminated with cooled‐transported semen at our facility returned for a routine pregnancy diagnosis at 15 days post ovulation. Ultrasonography per rectum revealed endometrial oedema and the absence of visual indication of a corpus luteum on either ovary. Nonetheless, an embryonic vesicle small for the gestational age was identified. Daily oral altrenogest treatment was implemented immediately. Serum progesterone concentration was 0.67 ng/ml, which is below the threshold considered adequate for pregnancy maintenance in the mare. Examinations were repeated at 17, 25, 30, 39, 49, 72 and 120 days post ovulation. At 25 days post ovulation the embryonic vesicle presented normal development for the gestational age. In addition, sequential blood samples were collected to measure progesterone, equine chorionic gonadotrophin and oestrone sulphate concentrations. Although progesterone concentration did not exceed 2 ng/ml until 72 days post ovulation, all other results were unremarkable and a healthy filly was born uneventfully at 344 days post ovulation.
ISSN:0425-1644
2042-3306
DOI:10.1111/j.2042-3306.2012.00559.x