Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring

The period around the time of conception is one characterised by considerable cytological and molecular restructuring as ovulation occurs, the oocyte is fertilised and the embryonic developmental programme begins. The intrinsic processes regulating peri-conceptional progression are supplemented by e...

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Bibliographic Details
Published in:Animal reproduction science 2012-02, Vol.130 (3-4), p.193-197
Main Authors: Fleming, T.P, Velazquez, M.A, Eckert, J.J, Lucas, E.S, Watkins, A.J
Format: Article
Language:English
Subjects:
Animal models
Animals
Animals, Newborn
conception
Developmental programming
Diet
Embryo
embryogenesis
environmental factors
Female
females
Fetal Development - physiology
Male
maternal nutrition
Maternal Nutritional Physiological Phenomena - physiology
Mice
Mouse
Nutrition
Obesity
Oocyte
oocytes
ovulation
Pregnancy
Prenatal Nutritional Physiological Phenomena - physiology
progeny
Rats
risk
Sheep
Sheep - physiology
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Summary:The period around the time of conception is one characterised by considerable cytological and molecular restructuring as ovulation occurs, the oocyte is fertilised and the embryonic developmental programme begins. The intrinsic processes regulating peri-conceptional progression are supplemented by environmental factors, which contribute important metabolic information that influences several aspects of the developmental programme. Indeed, there is growing evidence from different mammalian animal models, reviewed here, that the peri-conceptional environment mediated through maternal nutrition can modify development throughout gestation and affect the physiological and metabolic health of adult offspring. The concept that adult disease risk may owe its origin to the quality of peri-conceptional maternal nutrition is one, which merits further research for mechanistic understanding and devising preventive strategies.
ISSN:0378-4320
1873-2232
DOI:10.1016/j.anireprosci.2012.01.015