Impact of olive oil phenolic concentration on human plasmatic phenolic metabolites

► Three different functional phenol-enriched virgin olive oils were prepared. ► Phenolic metabolites pharmacokinetics was assessed in a randomised, cross-over study. ► A linear trend was observed for hydroxytyrosol sulfate, the main metabolite in plasma. ► A dose-dependent response of phenol metabol...

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Published in:Food chemistry 2012-12, Vol.135 (4), p.2922-2929
Main Authors: Rubió, Laura, Valls, Rosa- M., Macià, Alba, Pedret, Anna, Giralt, Montse, Romero, Maria-Paz, de la Torre, Rafael, Covas, Maria-Isabel, Solà, Rosa, Motilva, Maria-José
Format: Article
Language:English
Subjects:
Acetic acid
Adult
Antioxidants - analysis
Antioxidants - metabolism
Bioavailability
Biological and medical sciences
Cross-Over Studies
Dose-response
Fat industries
Feeding. Feeding behavior
Female
Food industries
Fundamental and applied biological sciences. Psychology
Humans
Male
Middle Aged
Olea
Olive Oil
Olive oil phenols
Phenols - blood
Phenols - pharmacokinetics
Plant Oils - chemistry
Plant Oils - metabolism
Plasma phenolic metabolites
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
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Summary:► Three different functional phenol-enriched virgin olive oils were prepared. ► Phenolic metabolites pharmacokinetics was assessed in a randomised, cross-over study. ► A linear trend was observed for hydroxytyrosol sulfate, the main metabolite in plasma. ► A dose-dependent response of phenol metabolites in human plasma was observed. Three different functional phenol-enriched virgin olive oils (FVOO) were prepared with a phenolic content of 250 (L-FVOO), 500 (M-FVOO), and 750mg (H-FVOO) total phenols/kg. In a randomised, cross-over study with 12 healthy volunteers, the pharmacokinetics of phenolic biological metabolites was assessed. An increasing linear trend was observed for hydroxytyrosol sulfate, the main phenolic metabolite quantified in plasma, with Cmax values of 1.35, 3.32, and 4.09μmol/l, and AUC mean values of 263.7, 581.4, and 724.4μmol/min for L-FVOO, M-FVOO, and H-FVOO, respectively. From our data an acute intake of phenol-enriched olive oils promotes a dose-dependent response of phenol conjugate metabolites in human plasma. Also, we point out for the first time hydroxytyrosol acetate sulfate as a main biological metabolite of hydroxytyrosol from olive oil ingestion.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2012.07.085