Prenatal Exposure to Arsenic and Its Effects on Fetal Development in the General Population of Dalian

To evaluate prenatal exposure to arsenic in the general population and its effects on birth size, we conducted a cross-sectional study in Dalian, China. Arsenic concentration in maternal and cord blood was detected by inductively coupled plasma-mass spectrometry and its effects on birth size were an...

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Bibliographic Details
Published in:Biological trace element research 2012-10, Vol.149 (1), p.10-15
Main Authors: Guan, Huai, Piao, Fengyuan, Zhang, Xuan, Li, Xiaowei, Li, Qiujuan, Xu, Lei, Kitamura, Fumihiko, Yokoyama, Kazuhito
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - epidemiology
Abortion, Spontaneous - metabolism
adverse effects
Arsenic
Arsenic - adverse effects
Arsenic - blood
Biochemistry
Biomedical and Life Sciences
Biotechnology
Birth weight
blood
Body Size
chest
China - epidemiology
Cross-Sectional Studies
environmental exposure
Female
Fetal Blood - metabolism
fetal development
Fetal Development - drug effects
Gestational Age
Head - anatomy & histology
head circumference
Human exposure
Humans
Life Sciences
Linear Models
Male
Mass spectrometry
Mass Spectrometry - methods
Maternal Exposure - adverse effects
Multivariate Analysis
Nutrition
Oncology
Pregnancy
Prenatal development
Prenatal exposure
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Exposure Delayed Effects - metabolism
Regression analysis
spectroscopy
Toxicity
uterus
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Summary:To evaluate prenatal exposure to arsenic in the general population and its effects on birth size, we conducted a cross-sectional study in Dalian, China. Arsenic concentration in maternal and cord blood was detected by inductively coupled plasma-mass spectrometry and its effects on birth size were analyzed by multivariate analysis and multiple linear regression analysis. Arsenic concentrations in cord blood were significantly lower than those in maternal blood. A significant positive correlation was shown between maternal and cord blood arsenic concentrations. Maternal arsenic concentration was negatively associated with birth weight, height and chest circumference, and fetal arsenic concentration was negatively associated with head circumference. Our results indicate that arsenic exposure at environmental levels in uterus may pose adverse effects on fetal development.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-012-9396-7