Ploidy and S-phase fraction are correlated with lymphovascular space invasion that is predictive of outcomes in endometrial cancer

Background Pathological detection of lymphovascular space invasion (LVSI) is a useful prognostic marker for patients with endometrial cancer. However, LVSI is criticized for its subjectivity and poor reproducibility. To improve the outcomes of patients with endometrial cancer, we evaluated objective...

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Published in:International journal of clinical oncology 2012-12, Vol.17 (6), p.590-597
Main Authors: Song, Taejong, Lee, Jeong-Won, Choi, Chel Hun, Kim, Tae-Joong, Bae, Duk-Soo, Sung, Chang Ohk, Song, Sang Yong, Kim, Byoung-Gie
Format: Article
Language:English
Subjects:
Aged
Cancer
Cancer Research
Disease-Free Survival
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Female
Humans
Lymphatic Metastasis
Lymphatic system
Lymphatic Vessels - pathology
Medicine
Medicine & Public Health
Middle Aged
Odds Ratio
Oncology
Original Article
Pathology
Ploidies
Prognosis
S Phase
Surgical Oncology
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Summary:Background Pathological detection of lymphovascular space invasion (LVSI) is a useful prognostic marker for patients with endometrial cancer. However, LVSI is criticized for its subjectivity and poor reproducibility. To improve the outcomes of patients with endometrial cancer, we evaluated objective parameters associated with LVSI to generate more accurate LVSI assessments and to identify patients with high-risk disease. Methods We reviewed the medical records of 137 patients with endometrial cancer. Flow cytometry was used to determine DNA ploidy and S-phase fraction. Estrogen and progesterone receptor (ER and PR) levels and p53 and k-ras mutational status were tested. Results LVSI was found in 36 patients (26.3%). Patients with LVSI had significantly decreased recurrence-free survival and overall survival compared to those without LVSI. Aneuploid tumors were significantly more frequent in LVSI-positive patients compared with LVSI-negative patients (odds ratio = 5.208, P  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-011-0329-9