Prognostic value of 18F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: Comparisons of volume-based metabolic parameters

Background The prognostic significance of volume‐based metabolic parameters measured by 18F‐fluorodeoxyglucose positron emission tomography/CT (18F‐FDG PET/CT) is not established. We evaluated the prognostic value of metabolic parameters in patients with squamous cell carcinoma (SCC) of the tonsil....

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Bibliographic Details
Published in:Head & neck 2013-01, Vol.35 (1), p.15-22
Main Authors: Moon, Seung Hwan, Choi, Joon Young, Lee, Hwan Joo, Son, Young-Ik, Baek, Chung-Hwan, Ahn, Yong Chan, Park, Keunchil, Lee, Kyung-Han, Kim, Byung-Tae
Format: Article
Language:English
Subjects:
18F-FDG
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - diagnostic imaging
Female
Fluorodeoxyglucose F18
Head and Neck Neoplasms - diagnostic imaging
Humans
Male
metabolic tumor volume
Middle Aged
Multimodal Imaging - methods
Palatine Tonsil - diagnostic imaging
Palatine Tonsil - pathology
PET/CT
Positron-Emission Tomography
Prognosis
prognosis prediction
Squamous Cell Carcinoma of Head and Neck
Survival Analysis
SUV
Tomography, X-Ray Computed
tonsil cancer
Tonsillar Neoplasms - diagnostic imaging
Tonsillar Neoplasms - radiotherapy
total lesion glycolysis
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Summary:Background The prognostic significance of volume‐based metabolic parameters measured by 18F‐fluorodeoxyglucose positron emission tomography/CT (18F‐FDG PET/CT) is not established. We evaluated the prognostic value of metabolic parameters in patients with squamous cell carcinoma (SCC) of the tonsil. Methods We enrolled a total of 69 patients with SCC of the tonsil who underwent pretreatment 18F‐FDG PET/CT. We measured maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and asymmetry indices (of SUVmax, MTV, and TLG). The prognostic significance of these parameters and clinical variables was assessed by Cox proportional hazards regression analysis. Results Multivariate analyses with adjustments for age, sex, and American Joint Committee on Cancer stage showed that only TLG (hazard ratio = 1.020, 95% confidence interval 1.003–1.037, p = .023) was an independent predictive factor associated with decreased overall survival. Conclusion TLG is a significant independent metabolic prognostic factor for overall survival in patients with SCC of the tonsil. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.22904