Combined measurements of serum bile acid level and splenic volume may be useful to noninvasively assess portal venous pressure

• Published in: Journal of gastroenterology 2012-12, Vol.47 (12), p.1336-1341
• Main Authors: Hayashi, Hiromitsu, Beppu, Toru, Okabe, Hirohisa, Nitta, Hidetoshi, Imai, Katsunori, Doi, Koichi, Chikamoto, Akira, Baba, Hideo
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Adult; Aged; Aged, 80 and over; Analysis; Bile acids; Bile Acids and Salts - blood; Biliary Tract; Colorectal Surgery; Gastroenterology; Health aspects; Hepatitis - complications; Hepatology; Humans; Hypertension; Hypertension, Portal - diagnosis; Hypertension, Portal - etiology; Liver; Liver cirrhosis; Liver Cirrhosis - complications; Measurement; Medicine; Medicine & Public Health; Mesenteric Veins; Middle Aged; Original Article—Liver; Pancreas; Portal Pressure - physiology; Povidone; Spleen - pathology; Splenic Vein; Surgical Oncology; Venous pressure
• ISSN: 0944-1174; 1435-5922
• DOI: 10.1007/s00535-012-0599-7

Background We aimed to identify a noninvasive predictor of portal venous pressure (PVP). Methods We directly measured the PVP in 40 consecutive patients who underwent direct percutaneous transhepatic portal vein puncture as part of the therapeutic management for liver diseases, and we evaluated the association of the PVP with noninvasive clinical parameters. The backgrounds of the liver were normal in 13 patients, chronic hepatitis in 17, and liver cirrhosis in ten. Results The mean PVP was 202 ± 114 mmH 2 O. In a multivariate linear regression analysis, the serum bile acid level and splenic volume showed independent positive correlations with the PVP ( P