Role of genomics on the path to personalized medicine

Abstract Technology continues to lead the field of personalized medicine as the interpretation of the human genome is progressing. The cost and duration of genomic sequencing continue to decrease sharply and there is intensive research aimed at understanding how the changes that occur within the gen...

Full description

Saved in:
Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2013, Vol.62, p.S2-S5
Main Authors: Tremblay, Johanne, Hamet, Pavel
Format: Article
Language:English
Subjects:
Delivery of Health Care - methods
Delivery of Health Care - standards
Delivery of Health Care - trends
Endocrinology & Metabolism
Gene-Environment Interaction
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing
Genetic Variation
Genetics
Genome, Human
Genomics
Health Behavior
Humans
Participatory Medicine
Personalized Health Care
Pharmacogenetics
Precision Medicine - methods
Precision Medicine - trends
Public Opinion
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Technology continues to lead the field of personalized medicine as the interpretation of the human genome is progressing. The cost and duration of genomic sequencing continue to decrease sharply and there is intensive research aimed at understanding how the changes that occur within the genome can alter its function and the genomic variations that constitute individual susceptibility to diseases and responses to therapy. The overlay of a personal genome with the personal medical record of patients has a potential to improve prediction and prevention and to allow a more pro-active therapeutic strategy. It is evident that pharmacogenomics and individualized drug therapy are the building blocks of personalized medicine. A growing number of drugs are now used for the treatment of cancer in subjects selected by a companion genetic test. Personalized medicine while based upon genomic knowledge of the individual requires equally essential personalised environmental information as well as the understanding of every subject's capacity for health-promoting behaviour.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2012.08.023