Inflammation-based prognostic system predicts survival after surgery for stage IV colorectal cancer

Abstract Background The aim of this study was to estimate whether the Glasgow prognostic score (GPS) is useful for predicting the survival of patients after surgery for stage IV colorectal cancer (CRC). Methods The GPS was calculated on the basis of admission data as follows: patients with both an i...

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Published in:The American journal of surgery 2013, Vol.205 (1), p.22-28
Main Authors: Ishizuka, Mitsuru, M.D, Nagata, Hitoshi, M.D, Takagi, Kazutoshi, M.D, Iwasaki, Yoshimi, M.D, Kubota, Keiichi, M.D
Format: Article
Language:English
Subjects:
Aged
Body mass index
C-Reactive Protein - analysis
Cancer therapies
Carbohydrates
Carcinoembryonic Antigen - blood
Classification
Colorectal cancer
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Decision making
Female
Glasgow prognostic score
Humans
Hypoalbuminemia - epidemiology
Inflammation - blood
Male
Multivariate Analysis
Pathology
Postoperative survival
Prognosis
Retrospective Studies
Stage IV colorectal cancer
Studies
Subclass
Surgery
Survival Analysis
Systemic inflammatory response
Tumors
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container_title The American journal of surgery
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creator Ishizuka, Mitsuru, M.D
Nagata, Hitoshi, M.D
Takagi, Kazutoshi, M.D
Iwasaki, Yoshimi, M.D
Kubota, Keiichi, M.D
description Abstract Background The aim of this study was to estimate whether the Glasgow prognostic score (GPS) is useful for predicting the survival of patients after surgery for stage IV colorectal cancer (CRC). Methods The GPS was calculated on the basis of admission data as follows: patients with both an increased C-reactive protein (CRP) level (>1.0 mg/dL) and hypoalbuminemia (
doi_str_mv 10.1016/j.amjsurg.2012.04.012
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Methods The GPS was calculated on the basis of admission data as follows: patients with both an increased C-reactive protein (CRP) level (&gt;1.0 mg/dL) and hypoalbuminemia (&lt;3.5 g/dL) were allocated a score of 2, and patients showing one or none of these abnormalities were allocated a score of 1 or 0, respectively. Results A total of 108 patients with stage IV CRC were enrolled. Although multivariate analyses showed that tumor pathology, subclass of stage IV CRC, and the GPS were associated with overall survival, the GPS could divide the patients into 3 independent groups showing significant differences in postoperative survival ( P = .018). Conclusions The GPS is not only one of the most significant clinical characteristics associated with the overall survival of patients with stage IV CRC, but also a useful indicator that is capable of dividing such patients into 3 independent groups before surgery.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2012.04.012</identifier><identifier>PMID: 23116639</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Body mass index ; C-Reactive Protein - analysis ; Cancer therapies ; Carbohydrates ; Carcinoembryonic Antigen - blood ; Classification ; Colorectal cancer ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Decision making ; Female ; Glasgow prognostic score ; Humans ; Hypoalbuminemia - epidemiology ; Inflammation - blood ; Male ; Multivariate Analysis ; Pathology ; Postoperative survival ; Prognosis ; Retrospective Studies ; Stage IV colorectal cancer ; Studies ; Subclass ; Surgery ; Survival Analysis ; Systemic inflammatory response ; Tumors</subject><ispartof>The American journal of surgery, 2013, Vol.205 (1), p.22-28</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-fbd69bc234fee8329f838708d9e52f50625e1fa48d3e8535f55df66e7ba5b6923</citedby><cites>FETCH-LOGICAL-c448t-fbd69bc234fee8329f838708d9e52f50625e1fa48d3e8535f55df66e7ba5b6923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23116639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishizuka, Mitsuru, M.D</creatorcontrib><creatorcontrib>Nagata, Hitoshi, M.D</creatorcontrib><creatorcontrib>Takagi, Kazutoshi, M.D</creatorcontrib><creatorcontrib>Iwasaki, Yoshimi, M.D</creatorcontrib><creatorcontrib>Kubota, Keiichi, M.D</creatorcontrib><title>Inflammation-based prognostic system predicts survival after surgery for stage IV colorectal cancer</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background The aim of this study was to estimate whether the Glasgow prognostic score (GPS) is useful for predicting the survival of patients after surgery for stage IV colorectal cancer (CRC). Methods The GPS was calculated on the basis of admission data as follows: patients with both an increased C-reactive protein (CRP) level (&gt;1.0 mg/dL) and hypoalbuminemia (&lt;3.5 g/dL) were allocated a score of 2, and patients showing one or none of these abnormalities were allocated a score of 1 or 0, respectively. Results A total of 108 patients with stage IV CRC were enrolled. Although multivariate analyses showed that tumor pathology, subclass of stage IV CRC, and the GPS were associated with overall survival, the GPS could divide the patients into 3 independent groups showing significant differences in postoperative survival ( P = .018). 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Methods The GPS was calculated on the basis of admission data as follows: patients with both an increased C-reactive protein (CRP) level (&gt;1.0 mg/dL) and hypoalbuminemia (&lt;3.5 g/dL) were allocated a score of 2, and patients showing one or none of these abnormalities were allocated a score of 1 or 0, respectively. Results A total of 108 patients with stage IV CRC were enrolled. Although multivariate analyses showed that tumor pathology, subclass of stage IV CRC, and the GPS were associated with overall survival, the GPS could divide the patients into 3 independent groups showing significant differences in postoperative survival ( P = .018). Conclusions The GPS is not only one of the most significant clinical characteristics associated with the overall survival of patients with stage IV CRC, but also a useful indicator that is capable of dividing such patients into 3 independent groups before surgery.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23116639</pmid><doi>10.1016/j.amjsurg.2012.04.012</doi><tpages>7</tpages></addata></record>
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source ScienceDirect Journals
subjects Aged
Body mass index
C-Reactive Protein - analysis
Cancer therapies
Carbohydrates
Carcinoembryonic Antigen - blood
Classification
Colorectal cancer
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Decision making
Female
Glasgow prognostic score
Humans
Hypoalbuminemia - epidemiology
Inflammation - blood
Male
Multivariate Analysis
Pathology
Postoperative survival
Prognosis
Retrospective Studies
Stage IV colorectal cancer
Studies
Subclass
Surgery
Survival Analysis
Systemic inflammatory response
Tumors
title Inflammation-based prognostic system predicts survival after surgery for stage IV colorectal cancer
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