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Methylglyoxal, cognitive function and cerebral atrophy in older people
The effects of advanced glycation endproducts on cognition and brain structure are poorly understood. We studied associations of the advanced glycation endproduct precursor methylglyoxal (MGO) with cognitive function and brain volumes in older people. Nondemented participants in the Tasmanian Study...
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| Published in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2013-01, Vol.68 (1), p.68-73 |
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| cited_by | cdi_FETCH-LOGICAL-c387t-c851e11860583579d585539802a6418c70b86e53677a9064763e78dde363ac873 |
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| container_end_page | 73 |
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| container_start_page | 68 |
| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Srikanth, Velandai Westcott, Bernadette Forbes, Josephine Phan, Thanh G Beare, Richard Venn, Alison Pearson, Sue Greenaway, Tim Parameswaran, Venkat Münch, Gerald |
| description | The effects of advanced glycation endproducts on cognition and brain structure are poorly understood. We studied associations of the advanced glycation endproduct precursor methylglyoxal (MGO) with cognitive function and brain volumes in older people.
Nondemented participants in the Tasmanian Study of Cognition and Gait underwent cognitive testing and brain magnetic resonance imaging scans. Brain volumes were obtained by magnetic resonance imaging scan segmentation and statistical parametric mapping procedures. Serum MGO was measured after derivatization to methylquinoxaline by high pressure liquid chromatography and UV detection. Linear regression was used to examine associations of log-transformed MGO with cognitive scores and brain volumes adjusting for potential confounding by age, sex, education, mood, insulin resistance, history of stroke, vascular risk factors, alcohol intake, and psychoactive medication use.
There were 378 participants, mean age 72.1 years (SD 7.1), 55% male. Greater MGO was associated with poorer memory (β = -.12, 95% confidence interval: -0.22, -0.02, p = .02) and executive function, the latter being greater among those with a history of stroke (MGO × stroke β = .48, 95% confidence interval: 0.17, 0.79, p = .002). Greater MGO was associated with lower grey matter volume (β = -6.42, 95% confidence interval -11.82, -1.11, p = .02) but not with white matter volume, white matter lesion volume, or hippocampal volume.
These results support the investigation of the role of the advanced glycation endproduct precursor methylglyoxal in cognitive decline and neurodegeneration in older people. |
| doi_str_mv | 10.1093/gerona/gls100 |
| format | article |
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Nondemented participants in the Tasmanian Study of Cognition and Gait underwent cognitive testing and brain magnetic resonance imaging scans. Brain volumes were obtained by magnetic resonance imaging scan segmentation and statistical parametric mapping procedures. Serum MGO was measured after derivatization to methylquinoxaline by high pressure liquid chromatography and UV detection. Linear regression was used to examine associations of log-transformed MGO with cognitive scores and brain volumes adjusting for potential confounding by age, sex, education, mood, insulin resistance, history of stroke, vascular risk factors, alcohol intake, and psychoactive medication use.
There were 378 participants, mean age 72.1 years (SD 7.1), 55% male. Greater MGO was associated with poorer memory (β = -.12, 95% confidence interval: -0.22, -0.02, p = .02) and executive function, the latter being greater among those with a history of stroke (MGO × stroke β = .48, 95% confidence interval: 0.17, 0.79, p = .002). Greater MGO was associated with lower grey matter volume (β = -6.42, 95% confidence interval -11.82, -1.11, p = .02) but not with white matter volume, white matter lesion volume, or hippocampal volume.
These results support the investigation of the role of the advanced glycation endproduct precursor methylglyoxal in cognitive decline and neurodegeneration in older people.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/gls100</identifier><identifier>PMID: 22496536</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aging - blood ; Aging - pathology ; Aging - psychology ; Atrophy ; Brain ; Brain - pathology ; Cognition ; Cognition & reasoning ; Female ; Gerontology ; Glycation End Products, Advanced - blood ; Humans ; Magnetic Resonance Imaging ; Male ; Neurodegeneration ; Neuropsychological Tests ; NMR ; Nuclear magnetic resonance ; Older people ; Pyruvaldehyde - blood</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2013-01, Vol.68 (1), p.68-73</ispartof><rights>Copyright Oxford University Press, UK Jan 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-c851e11860583579d585539802a6418c70b86e53677a9064763e78dde363ac873</citedby><cites>FETCH-LOGICAL-c387t-c851e11860583579d585539802a6418c70b86e53677a9064763e78dde363ac873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22496536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srikanth, Velandai</creatorcontrib><creatorcontrib>Westcott, Bernadette</creatorcontrib><creatorcontrib>Forbes, Josephine</creatorcontrib><creatorcontrib>Phan, Thanh G</creatorcontrib><creatorcontrib>Beare, Richard</creatorcontrib><creatorcontrib>Venn, Alison</creatorcontrib><creatorcontrib>Pearson, Sue</creatorcontrib><creatorcontrib>Greenaway, Tim</creatorcontrib><creatorcontrib>Parameswaran, Venkat</creatorcontrib><creatorcontrib>Münch, Gerald</creatorcontrib><title>Methylglyoxal, cognitive function and cerebral atrophy in older people</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>The effects of advanced glycation endproducts on cognition and brain structure are poorly understood. We studied associations of the advanced glycation endproduct precursor methylglyoxal (MGO) with cognitive function and brain volumes in older people.
Nondemented participants in the Tasmanian Study of Cognition and Gait underwent cognitive testing and brain magnetic resonance imaging scans. Brain volumes were obtained by magnetic resonance imaging scan segmentation and statistical parametric mapping procedures. Serum MGO was measured after derivatization to methylquinoxaline by high pressure liquid chromatography and UV detection. Linear regression was used to examine associations of log-transformed MGO with cognitive scores and brain volumes adjusting for potential confounding by age, sex, education, mood, insulin resistance, history of stroke, vascular risk factors, alcohol intake, and psychoactive medication use.
There were 378 participants, mean age 72.1 years (SD 7.1), 55% male. Greater MGO was associated with poorer memory (β = -.12, 95% confidence interval: -0.22, -0.02, p = .02) and executive function, the latter being greater among those with a history of stroke (MGO × stroke β = .48, 95% confidence interval: 0.17, 0.79, p = .002). Greater MGO was associated with lower grey matter volume (β = -6.42, 95% confidence interval -11.82, -1.11, p = .02) but not with white matter volume, white matter lesion volume, or hippocampal volume.
These results support the investigation of the role of the advanced glycation endproduct precursor methylglyoxal in cognitive decline and neurodegeneration in older people.</description><subject>Aged</subject><subject>Aging - blood</subject><subject>Aging - pathology</subject><subject>Aging - psychology</subject><subject>Atrophy</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Female</subject><subject>Gerontology</subject><subject>Glycation End Products, Advanced - blood</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neurodegeneration</subject><subject>Neuropsychological Tests</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Older people</subject><subject>Pyruvaldehyde - blood</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpdkD1PwzAURS0EoqUwsqJILAyE2nH8kRFVFJCKWEBii1znNU3l2sFOEPn3JEph4C33DUdXVwehS4LvCM7ovATvrJqXJhCMj9CUCCZjRtnHcf9jkcUMYz5BZyHs8HAsOUWTJEkzziifouULNNvOlKZz38rcRtqVtmqqL4g2rdVN5WykbBFp8LD2ykSq8a7edlFlI2cK8FENrjZwjk42ygS4OOQMvS8f3hZP8er18Xlxv4o1laKJtWQECJEcM0mZyAomGaOZxIniKZFa4LXk0A8TQmWYp4JTELIogHKqtBR0hm7G3tq7zxZCk--roMEYZcG1ISdJijMsE4579PofunOtt_26gUpSSaQcqHiktHcheNjkta_2ync5wfkgOB8F56Pgnr86tLbrPRR_9K9R-gMz3HZv</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Srikanth, Velandai</creator><creator>Westcott, Bernadette</creator><creator>Forbes, Josephine</creator><creator>Phan, Thanh G</creator><creator>Beare, Richard</creator><creator>Venn, Alison</creator><creator>Pearson, Sue</creator><creator>Greenaway, Tim</creator><creator>Parameswaran, Venkat</creator><creator>Münch, Gerald</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Methylglyoxal, cognitive function and cerebral atrophy in older people</title><author>Srikanth, Velandai ; Westcott, Bernadette ; Forbes, Josephine ; Phan, Thanh G ; Beare, Richard ; Venn, Alison ; Pearson, Sue ; Greenaway, Tim ; Parameswaran, Venkat ; Münch, Gerald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-c851e11860583579d585539802a6418c70b86e53677a9064763e78dde363ac873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aging - blood</topic><topic>Aging - pathology</topic><topic>Aging - psychology</topic><topic>Atrophy</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Female</topic><topic>Gerontology</topic><topic>Glycation End Products, Advanced - blood</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neurodegeneration</topic><topic>Neuropsychological Tests</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Older people</topic><topic>Pyruvaldehyde - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srikanth, Velandai</creatorcontrib><creatorcontrib>Westcott, Bernadette</creatorcontrib><creatorcontrib>Forbes, Josephine</creatorcontrib><creatorcontrib>Phan, Thanh G</creatorcontrib><creatorcontrib>Beare, Richard</creatorcontrib><creatorcontrib>Venn, Alison</creatorcontrib><creatorcontrib>Pearson, Sue</creatorcontrib><creatorcontrib>Greenaway, Tim</creatorcontrib><creatorcontrib>Parameswaran, Venkat</creatorcontrib><creatorcontrib>Münch, Gerald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. 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Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>68</volume><issue>1</issue><spage>68</spage><epage>73</epage><pages>68-73</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>The effects of advanced glycation endproducts on cognition and brain structure are poorly understood. We studied associations of the advanced glycation endproduct precursor methylglyoxal (MGO) with cognitive function and brain volumes in older people.
Nondemented participants in the Tasmanian Study of Cognition and Gait underwent cognitive testing and brain magnetic resonance imaging scans. Brain volumes were obtained by magnetic resonance imaging scan segmentation and statistical parametric mapping procedures. Serum MGO was measured after derivatization to methylquinoxaline by high pressure liquid chromatography and UV detection. Linear regression was used to examine associations of log-transformed MGO with cognitive scores and brain volumes adjusting for potential confounding by age, sex, education, mood, insulin resistance, history of stroke, vascular risk factors, alcohol intake, and psychoactive medication use.
There were 378 participants, mean age 72.1 years (SD 7.1), 55% male. Greater MGO was associated with poorer memory (β = -.12, 95% confidence interval: -0.22, -0.02, p = .02) and executive function, the latter being greater among those with a history of stroke (MGO × stroke β = .48, 95% confidence interval: 0.17, 0.79, p = .002). Greater MGO was associated with lower grey matter volume (β = -6.42, 95% confidence interval -11.82, -1.11, p = .02) but not with white matter volume, white matter lesion volume, or hippocampal volume.
These results support the investigation of the role of the advanced glycation endproduct precursor methylglyoxal in cognitive decline and neurodegeneration in older people.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>22496536</pmid><doi>10.1093/gerona/gls100</doi><tpages>6</tpages></addata></record> |
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| source | Oxford Journals Online |
| subjects | Aged Aging - blood Aging - pathology Aging - psychology Atrophy Brain Brain - pathology Cognition Cognition & reasoning Female Gerontology Glycation End Products, Advanced - blood Humans Magnetic Resonance Imaging Male Neurodegeneration Neuropsychological Tests NMR Nuclear magnetic resonance Older people Pyruvaldehyde - blood |
| title | Methylglyoxal, cognitive function and cerebral atrophy in older people |
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