Histopathology and ultrastructure of the liver under combined action of narcotics and hepatitis C and B viruses

Liver autopsy material from opioid addicts with viral hepatitis C and C+B showed hepatocyte dystrophy associated with lipid infiltration, hyperplasia of lymphoid tissue, and perivascular fibrosis. Alteration of hepatocytes were most pronounced in patients with hepatitis C+B. Ultrastructure of hepato...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-09, Vol.128 (3), p.963-966
Main Authors: Nepomnyashchikh, G. I., Tolokonskaya, N. P., Sakharova, E. G., Aidagulova, S. V., Mezentseva, G. A., Nepomnyashchikh, L. M.
Format: Article
Language:English
Subjects:
Addicts
Autopsy
Collagen
Dystrophy
Fibrosis
Hepatitis
Hepatitis C
Hepatocytes
Hyperplasia
Lipids
Liver
Lymphoid tissue
Medical research
Narcotics
Opioids
Ultrastructure
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Summary:Liver autopsy material from opioid addicts with viral hepatitis C and C+B showed hepatocyte dystrophy associated with lipid infiltration, hyperplasia of lymphoid tissue, and perivascular fibrosis. Alteration of hepatocytes were most pronounced in patients with hepatitis C+B. Ultrastructure of hepatocytes is characterized by a reduction of protein synthesizing compartment, an increase in volume density of smooth cytoplasmic reticulum, appearance of megamitochondria, and pronounced collagenization of the Disse space.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02438098